Akr1c1 Gene Summary [Rat]
Enables 17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase [NAD(P)+] activity and testosterone 17-beta-dehydrogenase (NADP+) activity. Involved in response to estrogen and response to xenobiotic stimulus. Located in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in 46,XY sex reversal 8; B-lymphoblastic leukemia/lymphoma; T-cell acute lymphoblastic leukemia; alcohol dependence; and leukemia. Orthologous to several human genes including AKR1C1 (aldo-keto reductase family 1 member C1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Akr1c1 |
| Official Name | aldo-keto reductase family 1, member C1 [Source:RGD Symbol;Acc:1306847] |
| Ensembl ID | ENSRNOG00000038331 |
| Bio databases IDs | |
| Aliases | aldo-keto reductase family 1, member C1 |
| Synonyms | 17beta-HSD-5, 20 α-HSD, 20 α SDH, 3alpha-HSD, Akr1c1, aldo-keto reductase family 1, member C1, aldo-keto reductase family 1, member C6, Hsd17b5 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Akr1c1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- 3(or 17)beta-hydroxysteroid dehydrogenase
- estradiol 17beta-dehydrogenase
- cortisone beta-reductase
- Aldo-keto reductase (AKR) superfamily
- trans-1,2-dihydrobenzene-1,2-diol dehydrogenase
- retinal dehydrogenase
- 3(or 17)alpha-hydroxysteroid dehydrogenase
- enzyme
- ketosteroid monooxygenase
- 15-hydroxyprostaglandin-D dehydrogenase (NADP)
- binding protein
- 20alpha-hydroxysteroid dehydrogenase
- aldo-keto reductase
- chlordecone reductase
- testosterone 17beta-dehydrogenase (NADP)
- ketoreductase
- Aldo/keto reductase family
- retinol dehydrogenase
- 3alpha-hydroxysteroid dehydrogenase (B-specific)
- geranylgeranyl reductase
- aldehyde reductase
- NADH or NADPH:quinone oxidoreductase
Pathways
Biological processes and signaling networks where the Akr1c1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- cytosol