Entpd5 Gene Summary [Mouse]
Enables GDP phosphatase activity and UDP phosphatase activity. Involved in UDP catabolic process. Acts upstream of with a positive effect on 'de novo' post-translational protein folding; UDP-alpha-D-glucose metabolic process; and protein N-linked glycosylation. Located in endoplasmic reticulum. Is expressed in several structures, including genitourinary system; gut; hemolymphoid system gland; liver; and nose. Orthologous to human ENTPD5 (ectonucleoside triphosphate diphosphohydrolase 5 (inactive)). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Entpd5 |
| Official Name | ectonucleoside triphosphate diphosphohydrolase 5 [Source:MGI Symbol;Acc:MGI:1321385] |
| Ensembl ID | ENSMUSG00000021236 |
| Bio databases IDs | |
| Aliases | ectonucleoside triphosphate diphosphohydrolase 5 |
| Synonyms | CD39L4, ectonucleoside triphosphate diphosphohydrolase 5, ectonucleoside triphosphate diphosphohydrolase 5 (inactive), ER-UDPase, mNTPase, NTPDase-5, Nucleotide diphophatase, PCPH |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Entpd5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- guanosine-diphosphatase
- nucleoside-diphosphatase
- apyrase
- uridine diphosphatase
- enzyme
- protein binding
- ASKHA_ATPase-like
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- epithelial cancer
- epithelial neoplasia
- hepatocellular carcinoma
- liver cancer
- hypoglycemia
- primary coenzyme Q10 deficiency type 6
- adenoma formation
- benign neoplasia
- prostatic intraepithelial neoplasia
regulated by
- phenobarbital
- Ca2+
- magnesium
- A549 cells
- NFE2L2
- troglitazone
- uranyl nitrate
- diethylnitrosamine
- polycystin
- 1,2-dithiole-3-thione
role in cell
- migration
- formation in
- invasion by
- proliferation
- growth
- apoptosis
- invasiveness
- adhesion
- colony formation
- function
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Extracellular Space
- Endoplasmic Reticulum
- endoplasmic reticulum lumen
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Entpd5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- nucleoside diphosphate catabolic process
- 'de novo' posttranslational protein folding
- UDP catabolic process
- protein N-linked glycosylation
- UDP-glucose metabolic process
Cellular Component
Where in the cell the gene product is active
- extracellular space
- membrane
- endoplasmic reticulum
- extracellular region
Molecular Function
What the gene product does at the molecular level
- protein binding
- adenosine-diphosphatase activity
- uridine-diphosphatase activity
- guanosine-diphosphatase activity
- nucleoside-triphosphatase activity