Ids Gene Summary [Mouse]
Enables iduronate-2-sulfatase activity. Involved in dermatan sulfate proteoglycan catabolic process and heparan sulfate proteoglycan catabolic process. Located in lysosome. Is active in lysosomal lumen. Is expressed in nervous system and neural retina. Used to study mucopolysaccharidosis II. Human ortholog(s) of this gene implicated in mucopolysaccharidosis II. Orthologous to human IDS (iduronate 2-sulfatase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ids |
| Official Name | iduronate 2-sulfatase [Source:MGI Symbol;Acc:MGI:96417] |
| Ensembl ID | ENSMUSG00000035847 |
| Bio databases IDs | |
| Aliases | iduronate 2-sulfatase |
| Synonyms | AW214631, ID2S, iduronate 2-sulfatase, Iduronate-2-sulphatase, MPS2, SIDS |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ids often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- alkaline phosphatases and sulfatases
- iduronate-2-sulfatase
- sulfuric ester hydrolase
- calcium ion binding
- Sulfatase
- enzyme
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
regulates
- glycosaminoglycan
- mineral
- chondroitin sulfate B
- heparan sulfate proteoglycan
disease
- mucopolysaccharidosis type II
- osteosclerosis
- glioblastoma
- glioblastoma cancer
- alopecia
- hereditary disorder
- otitis media with effusion
- mucopolysaccharidosis type I
- gait disturbance
- mucopolysaccharidosis type IIB
phenotypes
- abnormal appendicular skeleton morphology
- abnormal bone structure
- abnormal brain morphology
- abnormal brainstem morphology
- abnormal calcaneum morphology
- abnormal clavicle morphology
- abnormal coat/ hair morphology
- abnormal cranium morphology
- abnormal digit morphology
- abnormal gait
- abnormal glycosaminoglycan level
- abnormal hindlimb joint morphology
- abnormal joint morphology
- abnormal long bone diaphysis morphology
- abnormal lymph node morphology
- abnormal lysosome physiology
- abnormal mandible morphology
- abnormal neurocranium morphology
- abnormal neuron morphology
- abnormal skeleton morphology
- abnormal spatial working memory
- abnormal spinal cord morphology
- abnormal tendon morphology
- abnormal vertebrae morphology
- abnormal zygomatic bone morphology
- alopecia
- brain vacuoles
- broad snout
- calcified calcaneal tendon
- coarse facial features
- coarse hair
- decreased body size
- decreased body weight
- decreased cranium height
- decreased joint mobility
- distended urinary bladder
- enlarged neurocranium
- enlarged seminal vesicle
- exostosis
- hypoactivity
- increased anxiety-related response
- increased bone mineral content
- increased bone mineral density
- increased bone ossification
- increased brain weight
- increased diameter of long bones
- increased epididymis weight
- increased kidney weight
- increased liver weight
- increased lung weight
- increased spleen weight
- increased testis weight
- increased thyroid gland weight
- increased urine glycosaminoglycan level
- joint swelling
- lysosomal protein accumulation
- macrophthalmia
- osteosclerosis
- premature death
- round snout
- short stride length
role in cell
- formation
- proliferation
- function
- abnormal morphology
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- lysosome
- lysosomal compartment
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ids gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- dermatan sulfate catabolic process
- heparan sulfate proteoglycan catabolic process
- glycosaminoglycan catabolic process
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- lysosomal lumen
- lysosome
Molecular Function
What the gene product does at the molecular level
- protein binding
- calcium ion binding
- iduronate-2-sulfatase activity