Degs2 Gene Summary [Mouse]
Enables sphingolipid delta-4 desaturase activity. Acts upstream of or within sphinganine metabolic process and sphingolipid biosynthetic process. Predicted to be located in endoplasmic reticulum membrane. Is expressed in stomach. Orthologous to human DEGS2 (delta 4-desaturase, sphingolipid 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Degs2 |
| Official Name | delta(4)-desaturase, sphingolipid 2 [Source:MGI Symbol;Acc:MGI:1917309] |
| Ensembl ID | ENSMUSG00000021263 |
| Bio databases IDs | |
| Aliases | delta(4)-desaturase, sphingolipid 2 |
| Synonyms | 2210008A03Rik, C14orf66, delta 4-desaturase, sphingolipid 2, delta(4)-desaturase, sphingolipid 2, DES2, FADS8, RGD1305023, Sphingolipid δ(4)-desaturase/C4-hydroxylase DES2, δ 4-desaturase, sphingolipid 2, δ(4)-desaturase, sphingolipid 2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Degs2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- sphingolipid delta-4 desaturase
- Membrane-FADS-like
- Fatty acid desaturase
- enzyme
- Sphingolipid Delta4-desaturase (DES)
Pathways
Biological processes and signaling networks where the Degs2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- breast cancer
- androgenic alopecia
- survival
- sudden cardiac arrest
regulates
- ceramide
- C20:0 phytoceramide
- C30:0 phytoceramide
- C22:0 phytoceramide
- sphingolipid
- phytoceramide
- C34:1 phytoceramide
- C26:1 phytoceramide
- t18:0/26:0 ceramide
- C24:1 phytoceramide
role in cell
- proliferation
- cytotoxicity
- accumulation in
- binding in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- endoplasmic reticulum membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Degs2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- ceramide biosynthetic process
- sphinganine metabolic process
- sphingolipid biosynthetic process
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
Molecular Function
What the gene product does at the molecular level
- sphingolipid delta-4 desaturase activity
- sphingosine hydroxylase activity