Tle3 Gene Summary [Mouse]
Predicted to enable transcription corepressor activity. Involved in negative regulation of cold-induced thermogenesis. Predicted to be located in nucleoplasm. Predicted to be part of beta-catenin-TCF complex. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; genitourinary system; and sensory organ. Orthologous to human TLE3 (TLE family member 3, transcriptional corepressor). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tle3 |
| Official Name | transducin-like enhancer of split 3 [Source:MGI Symbol;Acc:MGI:104634] |
| Ensembl ID | ENSMUSG00000032280 |
| Bio databases IDs | |
| Aliases | transducin-like enhancer of split 3 |
| Synonyms | 2610103N05Rik, ESG, ESG3, Esp3, GRG3, Grg3a, Grg3b, HsT18976, mKIAA1547, TLE family member 3, transcriptional corepressor, transducin-like enhancer of split 3 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tle3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- WD40 repeats
- Groucho/TLE N-terminal Q-rich domain
- WD domain, G-beta repeat
- WD40
- protein binding
Pathways
Biological processes and signaling networks where the Tle3 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- papillary thyroid cancer
- hepatocellular carcinoma
- metastasis
- liver cancer
- epithelial cancer
- adenocarcinoma
- thyroid cancer
- glioma formation
- melanoma cancer
- testicular cancer
role in cell
- expression in
- differentiation
- phagocytosis by
- migration
- invasion by
- phagocytosis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tle3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of canonical Wnt receptor signaling pathway
- negative regulation of transcription, DNA-dependent
- signal transduction
- Wnt receptor signaling pathway
- organ morphogenesis
Cellular Component
Where in the cell the gene product is active
- nucleus
- transcription factor complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- transcription corepressor activity