Kdm3b Gene Summary [Mouse]
Predicted to enable several functions, including chromatin DNA binding activity; histone H3K9 demethylase activity; and transcription coregulator activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleoplasm. Predicted to be part of histone deacetylase complex. Predicted to be active in chromatin. Is expressed in several structures, including central nervous system; early conceptus; oocyte; and retina nuclear layer. Orthologous to human KDM3B (lysine demethylase 3B). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Kdm3b |
| Official Name | KDM3B lysine (K)-specific demethylase 3B [Source:MGI Symbol;Acc:MGI:1923356] |
| Ensembl ID | ENSMUSG00000038773 |
| Bio databases IDs | |
| Aliases | KDM3B lysine (K)-specific demethylase 3B |
| Synonyms | 5830462I21Rik, 5qNCA, C5orf7, DIJOS, JHDM2B, JMJD1B, Jumonji domain containing 1B, KDM3B lysine (K)-specific demethylase 3B, LOC102550630, LOC108353163, lysine demethylase 3B, mKIAA1082, NET22 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Kdm3b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- enzyme
- antioxidant enzyme
- RmlC-like cupin superfamily
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- abdominal cancer
- cancer
- Wilms tumorigenesis
- Diets-Jongmans syndrome
- urogenital cancer
- bipolar disorder
- tumorigenesis
- retroperitoneal cancer
- bipolar I disorder
- Wilms tumor
role in cell
- expression in
- proliferation
- growth
- abnormal morphology
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Kdm3b gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- chromatin remodeling
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- histone deacetylase complex
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- chromatin DNA binding
- transcription cofactor activity
- antioxidant activity
- metal ion binding
- histone demethylase activity (H3-K9 specific)