Mtr Gene Summary [Mouse]
Enables methionine synthase activity. Involved in cobalamin metabolic process. Acts upstream of or within methionine biosynthetic process. Predicted to be located in cytoplasm. Predicted to be active in cytosol. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in several diseases, including IgA glomerulonephritis; artery disease (multiple); autistic disorder; hematologic cancer (multiple); and hyperhomocysteinemia. Orthologous to human MTR (5-methyltetrahydrofolate-homocysteine methyltransferase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Mtr |
| Official Name | 5-methyltetrahydrofolate-homocysteine methyltransferase [Source:MGI Symbol;Acc:MGI:894292] |
| Ensembl ID | ENSMUSG00000021311 |
| Bio databases IDs | |
| Aliases | 5-methyltetrahydrofolate-homocysteine methyltransferase |
| Synonyms | 5-methyltetrahydrofolate-homocysteine methyltransferase, cblG, D830038K18Rik, HMAG, LOC149448, methioninesynthase, methyltetrahydrofolate-homocysteine methyltransferase, MS, MTR1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Mtr often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- methyltransferase cognate corrinoid proteins, Methanosarcina family
- vitamin binding
- metH
- homocysteine S-methyltransferase
- folic acid binding
- 5-methyltetrahydrofolate-homocysteine S-methyltransferase
- B12-binding_like
- enzyme
- protein binding
- Pterin binding enzyme
- betaine--homocysteine S-methyltransferase
- amino acid binding
- B12 binding domain
- methyltransferase
- binding protein
- Vitamin B12 dependent methionine synthase, activation domain
- 5-methyltetrahydrofolate--homocysteine methyltransferase
- tetrapyrrole binding
- Pterin_binding
Pathways
Biological processes and signaling networks where the Mtr gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- non-insulin-dependent diabetes mellitus
- impaired glucose tolerance
- atherosclerosis
- alcoholic liver disease
- liver disease
- HIV infection
- Crohn disease
- infection
- chronic hepatitis C
regulates
- L-methionine
- cyanocobalamin
- homocysteine
- L-tetrahydrofolic acid
- 5-methyltetrahydrofolic acid
- sulfur amino acid
role in cell
- regeneration
- response by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Mtr gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- methionine biosynthetic process
- cellular response to nitric oxide
- nervous system development
- tetrahydrofolate metabolic process
- cobalamin metabolic process
- response to axon injury
- homocysteine metabolic process
- axon regeneration
- methylation
Cellular Component
Where in the cell the gene product is active
- cytosol
Molecular Function
What the gene product does at the molecular level
- methionine synthase activity
- zinc ion binding
- protein binding
- cobalamin binding