Opn4 Gene Summary [Mouse]
Enables G protein-coupled photoreceptor activity. Involved in several processes, including hyaloid vascular plexus regression; optokinetic behavior; and phototransduction. Acts upstream of or within detection of temperature stimulus involved in thermoception; retina development in camera-type eye; and thermotaxis. Located in sperm head plasma membrane. Is expressed in eye and future brain. Orthologous to human OPN4 (opsin 4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Opn4 |
| Official Name | opsin 4 (melanopsin) [Source:MGI Symbol;Acc:MGI:1353425] |
| Ensembl ID | ENSMUSG00000021799 |
| Bio databases IDs | |
| Aliases | opsin 4 (melanopsin) |
| Synonyms | 1110007J02Rik, Gm533, Melanopsin, MOP, opsin 4, opsin 4 (melanopsin) |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Opn4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- G-protein coupled photoreceptor
- Cholecystokinin A receptor, N-terminal
- 7 transmembrane receptor (rhodopsin family)
- 11-cis retinal binding
- protein binding
- seven-transmembrane G protein-coupled receptor superfamily
Pathways
Biological processes and signaling networks where the Opn4 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- peripheral arterial disease
- Huntington disease
- esophageal adenocarcinoma
- esophageal carcinoma formation
- hypoxia
- productive infection by HIV-1
role in cell
- morphology
- regeneration
- abnormal morphology
- firing in
- firing
- action potential in
- light sensitivity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Opn4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- detection of temperature stimulus involved in thermoception
- cellular response to light stimulus
- rhythmic process
- G-protein coupled receptor signaling pathway
- retina development in camera-type eye
- thermotaxis
- detection of visible light
- regulation of circadian rhythm
- visual perception
- optokinetic behavior
- phototransduction
Cellular Component
Where in the cell the gene product is active
- dendrite
- membrane
- perikaryon
- plasma membrane
- axon
Molecular Function
What the gene product does at the molecular level
- 11-cis retinal binding
- protein binding
- G-protein coupled photoreceptor activity