Ubqln2 Gene Summary [Mouse]
Predicted to enable identical protein binding activity; molecular condensate scaffold activity; and polyubiquitin modification-dependent protein binding activity. Predicted to be involved in several processes, including negative regulation of receptor-mediated endocytosis; proteolysis involved in protein catabolic process; and regulation of catabolic process. Predicted to be located in cytoplasm and plasma membrane. Predicted to be active in cytosol. Is expressed in telencephalon. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis and amyotrophic lateral sclerosis type 15. Orthologous to human UBQLN2 (ubiquilin 2). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ubqln2 |
| Official Name | ubiquilin 2 [Source:MGI Symbol;Acc:MGI:1860283] |
| Ensembl ID | ENSMUSG00000050148 |
| Bio databases IDs | |
| Aliases | ubiquilin 2 |
| Synonyms | ALS15, CHAP1, DSK2, DSK2 homolog, HRIHFB2157, N4BP4, PLIC2, RGD1563566, ubiquilin 2, ubiquitin 2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ubqln2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- UBA domain-like superfamily
- Ubiquitin family
- collagen-like domain
- Ubl1_cv_Nsp3_N-like
- protein binding activity, bridging
- Ubiquitin homologues
- STI1 domain
- protein binding
- ubiquitin-like domain
- identical protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- amyotrophic lateral sclerosis type 15
- paralysis
- astrocytosis
- pathological denervation
- neonatal late-onset sepsis
role in cell
- migration
- proliferation
- assembly
- formation
- expression in
- phosphorylation in
- cell viability
- quantity
- accumulation in
- formation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- membrane fraction
- Cytoplasm
- perinuclear region
- Plasma Membrane
- cytosol
- cytoskeletal fraction
- cytoplasmic fraction
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ubqln2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- autophagic vacuole assembly
- negative regulation of clathrin-mediated endocytosis
- regulation of macroautophagy
- regulation of autophagic vacuole assembly
- ubiquitin-dependent protein catabolic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- cytoplasmic vesicle
- cytosol
- plasma membrane
- autophagic vacuole
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- polyubiquitin binding