Git2 Gene Summary [Mouse]
Predicted to enable GTPase activator activity and small GTPase binding activity. Involved in presynaptic modulation of chemical synaptic transmission and regulation of synaptic vesicle exocytosis. Acts upstream of or within behavioral response to pain. Is active in calyx of Held. Is expressed in genitourinary system. Orthologous to human GIT2 (GIT ArfGAP 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Git2 |
| Official Name | GIT ArfGAP 2 [Source:MGI Symbol;Acc:MGI:1347053] |
| Ensembl ID | ENSMUSG00000041890 |
| Bio databases IDs | |
| Aliases | GIT ArfGAP 2 |
| Synonyms | 1500036H07Rik, 5830420E16Rik, 6430510B20RIK, 9630056M03Rik, B230104M05Rik, CAT-2, GIT ArfGAP 2, mKIAA0148, p95PKL, PKL |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Git2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Ankyrin repeats (many copies)
- GIT coiled-coil Rho guanine nucleotide exchange factor
- paxillin-binding domain
- Ankyrin repeats (3 copies)
- Spa2 homology domain (SHD) of GIT
- protein binding
- GTPase-activating protein (GAP) for the ADP ribosylation factors (ARFs)
- binding protein
- G protein-coupled receptor kinase-interacting protein 1 C term
- Putative GTP-ase activating proteins for the small GTPase, ARF
- zinc finger domain
- PIX binding domain
- Putative GTPase activating protein for Arf
Pathways
Biological processes and signaling networks where the Git2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cardiovascular disorder
- hearing loss
- infection by fungus
role in cell
- activation in
- differentiation
- chemotaxis
- phosphorylation in
- migration
- function
- turnover
- invasion by
- persistence time
- exocytosis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- presynaptic regions
- cell periphery
- perinuclear region
- nucleoplasm
- axon terminals
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Git2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of ARF protein signal transduction
- brain development
- regulation of G-protein coupled receptor protein signaling pathway
Cellular Component
Where in the cell the gene product is active
- focal adhesion
- synapse
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding
- GTPase activator activity
- small GTPase binding