Ebf2 Gene Summary [Mouse]
Enables DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and chromatin binding activity. Involved in positive regulation of cold-induced thermogenesis and positive regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including adipose tissue development; brown fat cell differentiation; and positive regulation of DNA-templated transcription. Predicted to be located in nucleoplasm. Is expressed in several structures, including branchial arch; central nervous system; embryo mesenchyme; genitourinary system; and sensory organ. Orthologous to human EBF2 (EBF transcription factor 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ebf2 |
| Official Name | early B cell factor 2 [Source:MGI Symbol;Acc:MGI:894332] |
| Ensembl ID | ENSMUSG00000022053 |
| Bio databases IDs | |
| Aliases | early B cell factor 2 |
| Synonyms | COE2, D14Ggc1e, early B cell factor 2, EBF transcription factor 2, Mmot1, O/E-3, OE-3 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ebf2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- transcription regulator
- nucleic acid binding
- Transcription factor COE1 helix-loop-helix domain
- IPT
- chromatin binding
- Colier/Olf/Early B-cell factor (EBF) DNA Binding Domain
- protein binding
- sequence-specific DNA binding
- DNA binding
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- double-stranded DNA binding
- IPT/TIG domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- hypertension
- obesity
- epithelial cancer
- inguinal hernia
- prostate cancer
- metabolic syndrome X
- breast carcinoma
- cardiovascular disorder
- hypoplasia
phenotypes
- abnormal blood vessel morphology
- abnormal facial morphology
- abnormal head shape
- decreased mean corpuscular volume
- female infertility
- preweaning lethality incomplete penetrance
- shortened ST segment
- abnormal bone structure
- abnormal cerebellum anterior vermis morphology
- abnormal cerebellum morphology
- abnormal epididymis morphology
- abnormal fat cell morphology
- abnormal fertility/fecundity
- abnormal gait
- abnormal hypothalamus morphology
- abnormal hypothalamus secretion
- abnormal long bone epiphyseal plate morphology
- abnormal long bone morphology
- abnormal mean corpuscular volume
- abnormal neurite morphology
- abnormal olfactory bulb morphology
- abnormal olfactory epithelium morphology
- abnormal olfactory nerve morphology
- abnormal olfactory neuron innervation pattern
- abnormal olfactory sensory neuron morphology
- abnormal ovary size
- abnormal reproductive system morphology
- abnormal retina morphology
- abnormal sciatic nerve morphology
- abnormal seminiferous tubule morphology
- abnormal sexual interaction
- abnormal startle reflex
- abnormal testis morphology
- abnormal trabecular bone morphology
- decreased Purkinje cell number
- decreased body size
- decreased body weight
- decreased bone mineral density
- decreased bone strength
- decreased compact bone thickness
- decreased diameter of femur
- decreased nerve conduction velocity
- decreased neuron number
- hunched posture
- impaired coordination
- impaired neuron differentiation
- narcolepsy
- no abnormal phenotype detected
- postnatal growth retardation
- postnatal lethality incomplete penetrance
- short tibia
- small cerebellum
- small olfactory bulb
- testis hypoplasia
role in cell
- binding
- expression in
- differentiation
- activation in
- migration
- development
- abnormal morphology
- number
- conduction
- generation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
- chromatin
- perikaryon
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ebf2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- brown fat cell differentiation
- positive regulation of transcription from RNA polymerase II promoter
- cell fate determination
- adipose tissue development
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- chromatin
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- chromatin binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity