Adcy3 Gene Summary [Mouse]

Enables adenylate cyclase activity. Involved in several processes, including cAMP biosynthetic process; cellular response to forskolin; and olfactory learning. Acts upstream of or within sensory perception of smell. Located in ciliary membrane. Is expressed in several structures, including alimentary system; cardiovascular system; genitourinary system; nervous system; and sensory organ. Used to study major depressive disorder. Orthologous to human ADCY3 (adenylate cyclase 3). [provided by Alliance of Genome Resources, Jul 2025]

Details

Type
Retained Intron
Official Symbol
Adcy3
Official Name
adenylate cyclase 3 [Source:MGI Symbol;Acc:MGI:99675]
Ensembl ID
ENSMUSG00000020654
Bio databases IDs NCBI: 104111 Ensembl: ENSMUSG00000020654
Aliases adenylate cyclase 3
Synonyms AC3, ACIII, adenylate cyclase 3, mKIAA0511
Species
Mouse, Mus musculus

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Adcy3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • adenylate cyclase
  • calcium/calmodulin-responsive adenylate cyclase
  • Class III nucleotidyl cyclases
  • enzyme
  • protein binding
  • Adenylyl- / guanylyl cyclase, catalytic domain

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • obesity
  • myelin oligodendrocyte glycoprotein induced experimental autoimmune encephalomyelitis
  • hyperphagia
  • anosmia
  • asthenozoospermia
regulated by
regulates
  • cyclic AMP
  • NRP1
  • creatinine
  • renin
role in cell
  • formation
  • function
  • motility
  • elongation
  • excitatory postsynaptic potential
  • transmission
  • response by
  • cytostasis
  • projection
  • branching in

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Extracellular Space
  • Cytoplasm
  • cilia
  • cellular membrane
  • Plasma Membrane
  • Golgi Apparatus
  • axonemes
  • olfactory cilia
  • primary cilia
  • perikaryon
  • dendrites
  • dendritic knobs
  • sensory axons

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.