Orm1 Gene Summary [Mouse]
This gene encodes a member of the lipocalin family of proteins. The encoded protein is an abundant acute-phase protein that is synthesized by hepatocytes in response to cytokines during the acute phase response. The encoded protein may regulate inflammation and metabolism. This gene is present in a gene cluster on chromosome 4. [provided by RefSeq, Aug 2015]
Details
| Type | Protein Coding |
| Official Symbol | Orm1 |
| Official Name | orosomucoid 1 [Source:MGI Symbol;Acc:MGI:97443] |
| Ensembl ID | ENSMUSG00000039196 |
| Bio databases IDs | |
| Aliases | orosomucoid 1 |
| Synonyms | A1AG1, AAG, AGP, AGP1, Agp-2, AGP-A, Agpa1, alpha1 Acid Glycoprotein, Alpha1 Acid Glycoprotein A, Alpha Acid Glycoprotein, HEL-S-153w, OMD, ORM, orosomucoid 1, α 1 AGP, α Acid Glycoprotein |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Orm1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- binding protein
- lipocalin/cytosolic fatty acid-binding protein family
- protein binding
- Lipocalin / cytosolic fatty-acid binding protein family
Pathways
Biological processes and signaling networks where the Orm1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- Acute Phase Response Signaling
- Airway Pathology in Chronic Obstructive Pulmonary Disease
- Atherosclerosis Signaling
- Clathrin-mediated Endocytosis Signaling
- FXR/RXR Activation
- IL-12 Signaling and Production in Macrophages
- LXR/RXR Activation
- Production of Nitric Oxide and Reactive Oxygen Species in Macrophages
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- acute myeloid leukemia
- epithelial cancer
- organismal death
- specific granule deficiency
- acute coronary syndrome
- COVID-19
- liver cancer
- exercise intolerance
- sepsis
- hepatocellular carcinoma
regulated by
- Immunoglobulin
- insulin
- metribolone
- peripheral blood neutrophils
- TP53
- mercuric chloride
- lipopolysaccharide
- EGLN
- HFE
- gemfibrozil
role in cell
- quantity
- molecular cleavage in
- proliferation
- apoptosis
- migration
- binding
- epithelial-mesenchymal transition
- growth
- invasion by
- expression in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- secretory granule lumen
- organelle lumens
- alpha granules
- secretory vesicles
- specific granules
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Orm1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of interleukin-6 production
- inflammatory response
- positive regulation of tumor necrosis factor production
- regulation of immune system process
- acute-phase response
- positive regulation of interleukin-1 beta production
- negative regulation of tumor necrosis factor production
- positive regulation of interleukin-1 production
Cellular Component
Where in the cell the gene product is active
- platelet alpha granule lumen
- extracellular space
- extracellular vesicular exosome
- specific granule lumen
- blood microparticle
- extracellular region
Molecular Function
What the gene product does at the molecular level
- protein binding