Ntm Gene Summary [Mouse]
Predicted to be involved in negative regulation of neuron projection development. Predicted to be located in several cellular components, including cell surface; excitatory synapse; and perinuclear region of cytoplasm. Is expressed in several structures, including alimentary system; central nervous system; digit mesenchyme; heart; and sensory organ. Human ortholog(s) of this gene implicated in hypertension and primary open angle glaucoma. Orthologous to human NTM (neurotrimin). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ntm |
| Official Name | neurotrimin [Source:MGI Symbol;Acc:MGI:2446259] |
| Ensembl ID | ENSMUSG00000059974 |
| Bio databases IDs | |
| Aliases | neurotrimin |
| Synonyms | 6230410L23RIK, B230210G24RIK, CEPU-1, GP65, HNT, Igdcc2, IGLON2, neurotrimin, NTRI, RNU16845 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ntm often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- immunoglobulin domain
- Immunoglobulin like
- Immunoglobulin I-set domain
- protein binding
- identical protein binding
- Immunoglobulin V-set domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- acute myeloid leukemia
- COVID-19
- metabolic syndrome X
- insomnia
- schizophrenia
- prostate cancer
- sunburn
- non-Hodgkin disease
- idiopathic pulmonary fibrosis
- colorectal cancer
role in cell
- proliferation
- migration by
- development
- recognition
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- Extracellular Space
- perinuclear region
- presynaptic membrane
- synaptic membrane
- synapse
- axons
- excitatory synapses
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ntm gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- neuron recognition
- cell adhesion
Cellular Component
Where in the cell the gene product is active
- extracellular region
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding