Fgf17 Gene Summary [Mouse]

Predicted to enable growth factor activity; type 1 fibroblast growth factor receptor binding activity; and type 2 fibroblast growth factor receptor binding activity. Acts upstream of or within fibroblast growth factor receptor signaling pathway and positive regulation of cell population proliferation. Predicted to be located in extracellular region. Predicted to be active in cytoplasm and extracellular space. Is expressed in several structures, including arterial system; central nervous system; embryo mesenchyme; nose; and skeleton. Human ortholog(s) of this gene implicated in hypogonadotropic hypogonadism 20 with or without anosmia. Orthologous to human FGF17 (fibroblast growth factor 17). [provided by Alliance of Genome Resources, Jul 2025]

Details

Type
Protein Coding
Official Symbol
Fgf17
Official Name
fibroblast growth factor 17 [Source:MGI Symbol;Acc:MGI:1202401]
Ensembl ID
ENSMUSG00000022101
Bio databases IDs NCBI: 14171 Ensembl: ENSMUSG00000022101
Aliases fibroblast growth factor 17
Synonyms FGF-13, Fgf6b, fibroblast growth factor 17, HH20
Species
Mouse, Mus musculus
OrthologiesHumanRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Fgf17 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • beta-trefoil_FGF
  • type 2 fibroblast growth factor receptor binding
  • type 1 fibroblast growth factor receptor binding
  • protein binding
  • growth factor

Pathways

Biological processes and signaling networks where the Fgf17 gene in mouse plays a role, providing insight into its function and relevance in health or disease.

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
disease
  • Cornelia de Lange syndrome
  • gait disturbance
  • ataxia
  • hypogonadotropic hypogonadism 20
  • hypogonadotropic hypogonadism 20 without anosmia
  • susceptibility to Kallmann syndrome type 20
  • Kallmann syndrome type 20
regulated by
regulates
role in cell
  • phosphorylation in
  • proliferation
  • growth
  • survival
  • abnormal morphology
  • calcium spike in

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Extracellular Space

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the mouse Fgf17 gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • signal transduction
  • positive regulation of gene expression
  • positive regulation of cell proliferation
  • positive regulation of protein phosphorylation
  • cell-cell signaling
  • nervous system development
  • cell differentiation
  • fibroblast growth factor receptor signaling pathway
  • positive regulation of MAPK cascade
  • regulation of cell migration
  • organ morphogenesis

Cellular Component

Where in the cell the gene product is active
  • extracellular space
  • cytoplasm
  • extracellular region

Molecular Function

What the gene product does at the molecular level
  • growth factor activity
  • protein binding
  • type 2 fibroblast growth factor receptor binding
  • type 1 fibroblast growth factor receptor binding

Gene-Specific Assays for Results You Can Trust

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