Rpl17 Gene Summary [Mouse]
A structural constituent of ribosome. Predicted to be involved in positive regulation of G1/S transition of mitotic cell cycle. Located in cytoplasm. Part of cytosolic large ribosomal subunit. Is active in synapse. Is expressed in brain; central nervous system; embryo; pancreas epithelium; and retina. Orthologous to human RPL17 (ribosomal protein L17). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rpl17 |
| Official Name | ribosomal protein L17 [Source:MGI Symbol;Acc:MGI:2448270] |
| Ensembl ID | ENSMUSG00000062328 |
| Bio databases IDs | |
| Aliases | ribosomal protein L17 |
| Synonyms | ASI, L17, LOC100133240, PD-1, ribosomal protein L17, RPL23, uL22 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rpl17 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Ribosomal protein L22p/L17e
- structural constituent of ribosome
- rRNA binding
- protein binding
- Ribosomal_L22
Pathways
Biological processes and signaling networks where the Rpl17 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- aortic valve calcification
- acute graft-vs-host disease
- Parkinson disease
- metabolic syndrome X
- Klinefelter syndrome
- Diamond-Blackfan anemia
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- ribosome
- Nucleus
- sarcomere
- cytosol
- nucleoli
- synapse
- sensory axons
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Rpl17 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cytoplasmic translation
- translation
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytosolic ribosome
- cytoplasm
- cytosol
- cytosolic large ribosomal subunit
Molecular Function
What the gene product does at the molecular level
- RNA binding
- protein binding
- structural constituent of ribosome