Fgf17 Gene Summary [Rat]
Predicted to enable growth factor activity; type 1 fibroblast growth factor receptor binding activity; and type 2 fibroblast growth factor receptor binding activity. Predicted to be involved in several processes, including fibroblast growth factor receptor signaling pathway; positive regulation of MAPK cascade; and positive regulation of cell population proliferation. Predicted to be active in cytoplasm and extracellular space. Human ortholog(s) of this gene implicated in hypogonadotropic hypogonadism 20 with or without anosmia. Orthologous to human FGF17 (fibroblast growth factor 17). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Fgf17 |
| Official Name | fibroblast growth factor 17 [Source:RGD Symbol;Acc:2607] |
| Ensembl ID | ENSRNOG00000012912 |
| Bio databases IDs | |
| Aliases | fibroblast growth factor 17 |
| Synonyms | FGF-13, Fgf6b, fibroblast growth factor 17, HH20 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Fgf17 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- beta-trefoil_FGF
- type 2 fibroblast growth factor receptor binding
- type 1 fibroblast growth factor receptor binding
- protein binding
- growth factor
Pathways
Biological processes and signaling networks where the Fgf17 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Cornelia de Lange syndrome
- gait disturbance
- ataxia
- hypogonadotropic hypogonadism 20
- hypogonadotropic hypogonadism 20 without anosmia
- susceptibility to Kallmann syndrome type 20
- Kallmann syndrome type 20
role in cell
- phosphorylation in
- proliferation
- growth
- survival
- abnormal morphology
- calcium spike in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Fgf17 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- signal transduction
- positive regulation of gene expression
- positive regulation of cell proliferation
- positive regulation of protein phosphorylation
- cell-cell signaling
- nervous system development
- cell differentiation
- fibroblast growth factor receptor signaling pathway
- positive regulation of MAPK cascade
- regulation of cell migration
- organ morphogenesis
Cellular Component
Where in the cell the gene product is active
- extracellular space
- cytoplasm
- extracellular region
Molecular Function
What the gene product does at the molecular level
- growth factor activity
- protein binding
- type 2 fibroblast growth factor receptor binding
- type 1 fibroblast growth factor receptor binding