Fgfr2 Gene Summary [Mouse]
Enables fibroblast growth factor binding activity. Involved in several processes, including fibroblast growth factor receptor signaling pathway; forebrain generation of neurons; and positive regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including lung development; morphogenesis of an epithelium; and positive regulation of cell population proliferation. Located in excitatory synapse and nucleus. Is expressed in several structures, including alimentary system; brain; genitourinary system; sensory organ; and skeleton. Used to study Beare-Stevenson cutis gyrata syndrome; atopic dermatitis; intestinal atresia; and synostosis (multiple). Human ortholog(s) of this gene implicated in several diseases, including Beare-Stevenson cutis gyrata syndrome; breast cancer (multiple); gastrointestinal system cancer (multiple); reproductive organ cancer (multiple); and synostosis (multiple). Orthologous to human FGFR2 (fibroblast growth factor receptor 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Fgfr2 |
| Official Name | fibroblast growth factor receptor 2 [Source:MGI Symbol;Acc:MGI:95523] |
| Ensembl ID | ENSMUSG00000030849 |
| Bio databases IDs | |
| Aliases | fibroblast growth factor receptor 2 |
| Synonyms | BBDS, CD332, CEK3, CFD1, ECT1, Fgfr2 3c, Fgfr2b isoform, Fgfr2c isoform, Fgfr-7, fibroblast growth factor receptor 2, JWS, KGFRTr, K-SAM, svs, TK14, TK25 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Fgfr2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein-tyrosine kinase
- Protein kinase domain
- identical protein binding
- cytoplasmic domain
- ligand-binding domain
- Immunoglobulin like
- intracellular domain
- immunoglobulin-like protein domain
- membrane-proximal domain
- Tyrosine kinase, catalytic domain
- transmembrane receptor
- acid box domain
- extracellular domain
- type I intracellular domain
- Protein kinase (unclassified specificity)
- dimerization domain
- Protein tyrosine and serine/threonine kinase
- immunoglobulin domain
- ectodomain
- Immunoglobulin I-set domain
- autophosphorylation site
- protein binding
- acidic domain
- kinase
- Serine/Threonine protein kinases, catalytic domain
- kinase domain
- fibroblast growth factor receptor
- Protein Kinases, catalytic domain
- fibroblast growth factor binding
- transmembrane domain
- tyrosine kinase domain
- protein homodimerization
- glycosylation site
Pathways
Biological processes and signaling networks where the Fgfr2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- Adipogenesis pathway
- CREB Signaling in Neurons
- FGF Signaling
- Hepatic Fibrosis / Hepatic Stellate Cell Activation
- Human Embryonic Stem Cell Pluripotency
- IL-15 Production
- NF-κB Signaling
- PTEN Signaling
- Regulation of the Epithelial-Mesenchymal Transition Pathway
- Sperm Motility
- STAT3 Pathway
- Transcriptional Regulatory Network in Embryonic Stem Cells
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- atopic dermatitis
- tumorigenesis
- adenoma formation
- epithelial neoplasia
- head and neck neoplasia
- benign neoplasia
- growth failure
- pervasive developmental disorder
- glioblastoma
phenotypes
- abnormal Rathke's pouch apoptosis
- abnormal Rathke's pouch development
- abnormal adrenal gland development
- abnormal apical ectodermal ridge morphology
- abnormal appendicular skeleton morphology
- abnormal axial skeleton morphology
- abnormal basicranium morphology
- abnormal basisphenoid bone morphology
- abnormal bone ossification
- abnormal brain morphology
- abnormal branching involved in seminal vesicle morphogenesis
- abnormal bronchiole morphology
- abnormal cecum development
- abnormal cerebral hemisphere morphology
- abnormal chondrocyte morphology
- abnormal clavicle morphology
- abnormal cochlea morphology
- abnormal cochlear sensory epithelium morphology
- abnormal conotruncal ridge morphology
- abnormal coronal suture morphology
- abnormal corpus callosum morphology
- abnormal cranial cartilage development
- abnormal cranial cartilage morphology
- abnormal cranial synchondrosis
- abnormal craniofacial morphology
- abnormal cranium morphology
- abnormal decidualization
- abnormal dermis papillary layer morphology
- abnormal developmental patterning
- abnormal digestive system morphology
- abnormal ear development
- abnormal egg cylinder morphology
- abnormal embryo development
- abnormal endochondral bone ossification
- abnormal endoderm development
- abnormal endolymphatic duct morphology
- abnormal epidermal layer morphology
- abnormal epidermis stratum basale morphology
- abnormal epidermis stratum corneum morphology
- abnormal facial morphology
- abnormal frontal bone morphology
- abnormal hair follicle development
- abnormal hair follicle morphology
- abnormal head morphology
- abnormal head shape
- abnormal heart development
- abnormal heart ventricle morphology
- abnormal ilium morphology
- abnormal interventricular groove morphology
- abnormal intestinal glucose absorption
- abnormal ischium morphology
- abnormal keratinocyte morphology
- abnormal kidney cortex morphology
- abnormal kidney development
- abnormal lateral nasal gland morphology
- abnormal left posterior bundle morphology
- abnormal limb development
- abnormal liver development
- abnormal long bone epiphyseal ossification zone morphology
- abnormal long bone epiphyseal plate proliferative zone
- abnormal long bone epiphysis morphology
- abnormal lung development
- abnormal lung morphology
- abnormal mammary gland bud morphology
- abnormal mammary placode morphology
- abnormal membranous labyrinth morphology
- abnormal midface morphology
- abnormal nasal bone morphology
- abnormal nasal capsule morphology
- abnormal nasal gland morphology
- abnormal nasal septum cartilage morphology
- abnormal nasomaxillary suture morphology
- abnormal neurocranium morphology
- abnormal osteoblast physiology
- abnormal osteoblast proliferation
- abnormal otic capsule morphology
- abnormal otic vesicle development
- abnormal palatal shelf fusion at midline
- abnormal palate development
- abnormal palate morphology
- abnormal palatine bone horizontal plate morphology
- abnormal palatine bone morphology
- abnormal pancreas development
- abnormal pelvic girdle bone morphology
- abnormal perineum morphology
- abnormal pituitary gland development
- abnormal placenta development
- abnormal placenta morphology
- abnormal placenta vasculature
- abnormal presphenoid bone morphology
- abnormal prostate gland branching morphogenesis
- abnormal pulmonary acinus morphology
- abnormal pulmonary circulation
- abnormal rectum morphology
- abnormal respiration
- abnormal right lung morphology
- abnormal salivary gland morphology
- abnormal scapula morphology
- abnormal secondary palate development
- abnormal semicircular canal morphology
- abnormal seminal vesicle development
- abnormal seminal vesicle morphology
- abnormal seminal vesicle muscle layer morphology
- abnormal skin morphology
- abnormal sphenoid bone morphology
- abnormal spongiotrophoblast layer morphology
- abnormal sternebra morphology
- abnormal sternum manubrium morphology
- abnormal sternum morphology
- abnormal sternum ossification
- abnormal stomach glandular region morphology
- abnormal stomach morphology
- abnormal submandibular duct morphology
- abnormal synaptic vesicle clustering
- abnormal synaptic vesicle number
- abnormal synchondrosis
- abnormal thymus development
- abnormal tongue morphology
- abnormal trabecula carnea morphology
- abnormal trabecular bone morphology
- abnormal tracheal cartilage morphology
- abnormal trophoblast layer morphology
- abnormal truncus arteriosus septation
- abnormal umbilical cord morphology
- abnormal urethra morphology
- abnormal vertebrae morphology
- abnormal vestibulocochlear ganglion morphology
- abnormal vibrissa number
- abnormal xiphoid process morphology
- abnormal zygomatic arch morphology
- absent Rathke's pouch
- absent acromion
- absent adenohypophysis
- absent apical ectodermal ridge
- absent blastocoele
- absent exorbital lacrimal gland
- absent eyelids
- absent forelimb
- absent hindlimb
- absent hypodermis muscle layer
- absent lacrimal glands
- absent limb buds
- absent limbs
- absent lungs
- absent mammary gland
- absent palatal rugae
- absent placental labyrinth
- absent presphenoid bone
- absent primitive endoderm
- absent pubis
- absent pulmonary artery
- absent pulmonary vein
- absent rectum
- absent submandibular gland
- absent teeth
- absent thyroid gland
- acanthosis
- arrest of tooth development
- atrium hypoplasia
- caudal vertebral fusion
- cecal atresia
- cervical vertebral fusion
- cleft palate
- cleft secondary palate
- conotruncal ridge hypoplasia
- curly tail
- decreased birth body size
- decreased body size
- decreased body weight
- decreased brain size
- decreased cranium height
- decreased cranium length
- decreased embryo size
- decreased fetal size
- decreased hair follicle number
- decreased molar number
- decreased nephron number
- decreased osteoblast cell number
- decreased palatal length
- decreased prostate gland duct number
- decreased renal glomerulus number
- decreased skin pigmentation
- decreased width of hypertrophic chondrocyte zone
- delayed bone ossification
- delayed cranial suture closure
- delayed intramembranous bone ossification
- dilated distal convoluted tubules
- dilated proximal convoluted tubules
- domed cranium
- double outlet right ventricle
- embryonic growth retardation
- embryonic lethality between implantation and somite formation complete penetrance
- embryonic lethality during organogenesis complete penetrance
- enhanced osteoblast differentiation
- enlarged allantois
- enlarged fourth ventricle
- enlarged lateral ventricles
- epidermal hyperplasia
- epidermis stratum granulosum hyperplasia
- epidermis stratum spinosum hyperplasia
- exophthalmos
- eyelids open at birth
- failure of chorioallantoic fusion
- fused joints
- fused tracheal cartilage rings
- hypoglycemia
- hypospadia
- impaired branching involved in trachea morphogenesis
- impaired lung alveolus development
- impaired lung lobe morphogenesis
- increased cranium height
- increased cranium width
- increased osteoblast cell number
- increased prostate gland weight
- increased trophoblast giant cell number
- inner cell mass degeneration
- inner ear cysts
- lethality throughout fetal growth and development
- long incisors
- malocclusion
- midface hypoplasia
- muscular ventricular septal defect
- neonatal lethality
- neonatal lethality complete penetrance
- no abnormal phenotype detected
- ocular hypertelorism
- overriding aortic valve
- palatal shelf fusion with tongue or mandible
- palatal shelves fail to meet at midline
- perimembraneous ventricular septal defect
- perinatal lethality complete penetrance
- postnatal growth retardation
- postnatal lethality complete penetrance
- postnatal lethality incomplete penetrance
- premature coronal suture closure
- premature cranial suture closure
- premature death
- premature intramembranous bone ossification
- premature squamoparietal suture closure
- premature zygomaticomaxillary suture closure
- primary sex reversal
- pulmonary hypoplasia
- respiratory distress
- respiratory failure
- shallow orbits
- short basicranium
- short face
- short maxilla
- short rostral-caudal axis
- short snout
- shortened head
- slow postnatal weight gain
- small frontal bone
- small kidney
- small lung
- small otic capsule
- small otic vesicle
- small pancreas
- small parietal bone
- small scapula
- small stomach
- split sternal manubrium
- split sternum
- split xiphoid process
- submandibular gland hypoplasia
- syndactyly
- thick epidermis
- thick nasal septum
- thin dermal layer
- thin epidermis
- thin skin
- thin ventricular wall
- tongue ankylosis
- translucent skin
- ventricular hypoplasia
- vertebral fusion
- wide cranial sutures
role in cell
- phosphorylation in
- cell viability
- proliferation
- expression in
- morphology
- survival
- growth
- degradation in
- cell death
- apoptosis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- cell surface
- Extracellular Space
- cellular membrane
- cell cortex
- Nucleus
- vesicles
- Endoplasmic Reticulum
- trans Golgi network
- nuclear scaffolds
- extracellular matrix
- excitatory synapses
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Fgfr2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- lung-associated mesenchyme development
- post-embryonic development
- branching morphogenesis of a nerve
- prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis
- prostate epithelial cord elongation
- regulation of smoothened signaling pathway
- squamous basal epithelial stem cell differentiation involved in prostate gland acinus development
- in utero embryonic development
- axonogenesis
- mesenchymal cell differentiation
- positive regulation of epithelial cell proliferation
- fibroblast growth factor receptor signaling pathway involved in mammary gland specification
- cell-cell signaling
- prostate gland morphogenesis
- mesenchymal cell differentiation involved in lung development
- mesenchymal cell proliferation involved in lung development
- hair follicle morphogenesis
- epithelial to mesenchymal transition
- organ growth
- positive regulation of cell proliferation
- regulation of smooth muscle cell differentiation
- positive regulation of cell cycle
- positive regulation of transcription from RNA polymerase II promoter
- epithelial cell proliferation involved in salivary gland morphogenesis
- regulation of osteoblast differentiation
- branch elongation involved in salivary gland morphogenesis
- outflow tract septum morphogenesis
- membranous septum morphogenesis
- positive regulation of cell division
- angiogenesis
- positive regulation of phospholipase activity
- orbitofrontal cortex development
- embryonic cranial skeleton morphogenesis
- gland morphogenesis
- positive regulation of MAPK cascade
- skeletal system morphogenesis
- ureteric bud development
- cellular response to retinoic acid
- otic vesicle formation
- cell fate commitment
- response to lipopolysaccharide
- peptidyl-tyrosine phosphorylation
- positive regulation of cardiac muscle cell proliferation
- branching involved in prostate gland morphogenesis
- ventricular cardiac muscle tissue morphogenesis
- bud elongation involved in lung branching
- protein autophosphorylation
- fibroblast growth factor receptor signaling pathway
- embryonic digestive tract morphogenesis
- branching involved in salivary gland morphogenesis
- regulation of morphogenesis of a branching structure
- lateral sprouting from an epithelium
- embryonic organ morphogenesis
- lung alveolus development
- midbrain development
- digestive tract development
- lacrimal gland development
- apoptotic process
- morphogenesis of embryonic epithelium
- cellular response to hypoxia
- reproductive structure development
- embryonic pattern specification
- branching involved in labyrinthine layer morphogenesis
- positive regulation of canonical Wnt receptor signaling pathway
- embryonic organ development
- positive regulation of mesenchymal cell proliferation
- pyramidal neuron development
- organ morphogenesis
- epithelial cell differentiation
- cellular response to transforming growth factor beta stimulus
- endochondral bone growth
- epidermis morphogenesis
- mesodermal cell differentiation
- inner ear morphogenesis
- positive regulation of Wnt receptor signaling pathway
- regulation of osteoblast proliferation
- lung lobe morphogenesis
- multicellular organismal development
- bone morphogenesis
- odontogenesis
- positive regulation of epithelial cell proliferation involved in lung morphogenesis
- bone development
- negative regulation of keratinocyte proliferation
- negative regulation of transcription from RNA polymerase II promoter
- response to ethanol
- positive regulation of kinase activity
- lung development
- bone mineralization
- limb bud formation
- ventricular zone neuroblast division
- transmembrane receptor protein tyrosine kinase signaling pathway
- mammary gland bud formation
- regulation of ERK1 and ERK2 cascade
- fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development
- positive regulation of ERK1 and ERK2 cascade
- fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptotic process in bone marrow
- fibroblast growth factor receptor signaling pathway involved in hemopoiesis
- fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- cell cortex
- membrane
- excitatory synapse
- cytoplasmic vesicle
- Golgi apparatus
- receptor complex
- extracellular region
- plasma membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- fibroblast growth factor-activated receptor activity
- ATP binding
- protein tyrosine kinase activity
- protein homodimerization activity
- protein binding
- heparin binding
- fibroblast growth factor binding