Trmu Gene Summary [Mouse]
Predicted to enable ATP binding activity; tRNA binding activity; and tRNA-5-taurinomethyluridine 2-sulfurtransferase. Predicted to be involved in tRNA wobble position uridine thiolation. Located in mitochondrion. Used to study liver disease. Human ortholog(s) of this gene implicated in aminoglycoside-induced deafness; infantile liver failure syndrome; and transient infantile liver failure. Orthologous to human TRMU (tRNA mitochondrial 2-thiouridylase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | Trmu |
| Official Name | tRNA 5-methylaminomethyl-2-thiouridylate methyltransferase [Source:MGI Symbol;Acc:MGI:1919276] |
| Ensembl ID | ENSMUSG00000022386 |
| Bio databases IDs | |
| Aliases | tRNA 5-methylaminomethyl-2-thiouridylate methyltransferase |
| Synonyms | 1110005N20RIK, 1600025P05Rik, LCAL3, MTO2, MTU1, onco-lncRNA-1, TRMT, TRMT1, tRNA 5-methylaminomethyl-2-thiouridylate methyltransferase, tRNA mitochondrial 2-thiouridylase |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Trmu often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- tRNA methyl transferase HUP domain
- tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase
- tRNA methyl transferase PRC-barrel domain
- Aminomethyltransferase beta-barrel domain
- enzyme
- protein binding
- Adenine nucleotide alpha hydrolase (AANH) superfamily
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- squamous cell lung cancer
- hereditary disorder
- transient infantile liver failure
- reversible infantile cytochrome c oxidase deficiency
- lung adenocarcinoma
- lung adenocarcinoma formation
- preeclampsia
- urothelial bladder carcinoma
- transitional cell bladder cancer
- lung squamous cell carcinoma
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Trmu gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- tRNA wobble position uridine thiolation
Cellular Component
Where in the cell the gene product is active
- mitochondrion
Molecular Function
What the gene product does at the molecular level
- ATP binding
- tRNA binding