Mapk14 Gene Summary [Mouse]
Enables MAP kinase activity and NFAT protein binding activity. Involved in several processes, including negative regulation of canonical Wnt signaling pathway; positive regulation of cell differentiation; and skeletal system development. Acts upstream of or within several processes, including cell surface receptor signaling pathway; positive regulation of cell differentiation; and positive regulation of macromolecule biosynthetic process. Located in mitochondrion; nucleus; and spindle pole. Is active in cytosol and glutamatergic synapse. Is expressed in several structures, including alimentary system; early conceptus; genitourinary system; head mesenchyme; and telencephalon. Human ortholog(s) of this gene implicated in colon cancer; colorectal carcinoma; nasopharynx carcinoma; and rectum cancer. Orthologous to human MAPK14 (mitogen-activated protein kinase 14). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Mapk14 |
| Official Name | mitogen-activated protein kinase 14 [Source:MGI Symbol;Acc:MGI:1346865] |
| Ensembl ID | ENSMUSG00000053436 |
| Bio databases IDs | |
| Aliases | mitogen-activated protein kinase 14 |
| Synonyms | CRK1, CSBP, CSBP1, CSBP2, CSPB1, EXIP, Hog, LOC101929346, MAPK p38, mitogen-activated protein kinase 14, Mxi2, p38, p38a, p38ALPHA, p38Hog, p38 kinase, p38 MAPK, P38 Map Kinase, p38 MAP kinases alpha and beta, p38 MAP kinases α and β, p38 MAPK-α, p38-α, PRKM14, PRKM15, RK, SAPK2A, SAPK p38 alpha, SAPK p38 α |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Mapk14 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein serine/threonine kinase
- activation domain
- Protein kinase (unclassified specificity)
- protein kinase
- ATP-binding domain
- Protein tyrosine and serine/threonine kinase
- protein phosphatase binding
- mitogen-activated protein kinase p38 binding
- ATP binding
- threonine-glycine-tyrosine activation motif
- enzyme binding
- transcription factor binding
- common docking domain
- protein binding
- Protein kinase domain
- phosphorylation site
- kinase
- MAP kinase kinase
- Serine/Threonine protein kinases, catalytic domain
- kinase domain
- Protein Kinases, catalytic domain
- MAP kinase
- Tyrosine kinase, catalytic domain
Pathways
Biological processes and signaling networks where the Mapk14 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- Amyloid Processing
- April Mediated Signaling
- B Cell Activating Factor Signaling
- Cancer Drug Resistance By Drug Efflux
- CDK5 Signaling
- CNTF Signaling
- Corticotropin Releasing Hormone Signaling
- Ephrin B Signaling
- ErbB4 Signaling
- FGF Signaling
- GADD45 Signaling
- Glucocorticoid Receptor Signaling
- IL-17A Signaling in Gastric Cells
- JAK/Stat Signaling
- LPS-stimulated MAPK Signaling
- Melatonin Signaling
- MIF Regulation of Innate Immunity
- Mouse Embryonic Stem Cell Pluripotency
- Neurotrophin/TRK Signaling
- Oncostatin M Signaling
- Parkinson's Signaling
- PEDF Signaling
- Role of IL-17F in Allergic Inflammatory Airway Diseases
- Role of JAK family kinases in IL-6-type Cytokine Signaling
- Semaphorin Signaling in Neurons
- VEGF Family Ligand-Receptor Interactions
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- epithelial neoplasia
- cancer
- spontaneous hypertension
- myocardial infarction
- heart failure
- collagen-induced arthritis
- obesity
- dilated cardiomyopathy
- fibrosis
role in cell
- accumulation in
- recruitment
- activation in
- expression in
- phosphorylation in
- production in
- apoptosis
- tyrosine phosphorylation in
- cell spreading
- migration
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- nuclear fraction
- glutaminergic synapse
- secretory granule lumen
- ficolin-1-rich granule lumen
- Extracellular Space
- perinuclear region
- focal adhesions
- cell cortex
- Nucleus
- Mitochondria
- cytosol
- nucleoplasm
- spindle pole
- nuclear speckles
- neurites
- Z line
- C fiber
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Mapk14 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of cardiac muscle cell proliferation
- positive regulation of cyclase activity
- positive regulation of brown fat cell differentiation
- response to muramyl dipeptide
- signal transduction in response to DNA damage
- transcription from RNA polymerase II promoter
- regulation of cytokine production involved in inflammatory response
- transmembrane receptor protein serine/threonine kinase signaling pathway
- glucose metabolic process
- positive regulation of erythrocyte differentiation
- cellular response to UV-B
- cartilage condensation
- apoptotic process
- response to muscle stretch
- intracellular signal transduction
- stress-activated MAPK cascade
- positive regulation of protein import into nucleus
- p38MAPK cascade
- cell morphogenesis
- DNA damage checkpoint
- vascular endothelial growth factor receptor signaling pathway
- fatty acid oxidation
- positive regulation of gene expression
- lipopolysaccharide-mediated signaling pathway
- peptidyl-serine phosphorylation
- cellular senescence
- chondrocyte differentiation
- positive regulation of myoblast differentiation
- response to dietary excess
- placenta development
- positive regulation of transcription from RNA polymerase II promoter
- bone development
- chemotaxis
- response to insulin stimulus
- striated muscle cell differentiation
- stem cell differentiation
- angiogenesis
- cellular response to ionizing radiation
- positive regulation of myotube differentiation
- osteoblast differentiation
- cellular response to tumor necrosis factor
- platelet activation
- positive regulation of muscle cell differentiation
- positive regulation of reactive oxygen species metabolic process
- negative regulation of hippo signaling cascade
- 3'-UTR-mediated mRNA stabilization
- stress-activated protein kinase signaling cascade
- signal transduction
- stress-induced premature senescence
- positive regulation of glucose import
- cell surface receptor signaling pathway
- glucose import
- positive regulation of blood vessel endothelial cell migration
- regulation of transcription from RNA polymerase II promoter
- osteoclast differentiation
- negative regulation of canonical Wnt receptor signaling pathway
- negative regulation of inflammatory response to antigenic stimulus
- positive regulation of interleukin-12 production
- cellular response to lipopolysaccharide
- cellular response to lipoteichoic acid
- skeletal muscle tissue development
- cellular response to vascular endothelial growth factor stimulus
- regulation of ossification
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- nuclear speck
- mitochondrion
- spindle pole
- cytosol
- secretory granule lumen
- extracellular region
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein binding
- protein phosphatase binding
- mitogen-activated protein kinase p38 binding
- MAP kinase kinase activity
- MAP kinase activity
- NFAT protein binding
- protein serine/threonine kinase activity
- enzyme binding