Grina Gene Summary [Mouse]
Enables transmembrane transporter binding activity. Acts upstream of or within endoplasmic reticulum calcium ion homeostasis and negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway. Located in Golgi apparatus and endoplasmic reticulum. Is expressed in cerebral cortex; genitourinary system; and heart valve. Orthologous to human GRINA (glutamate ionotropic receptor NMDA type subunit associated protein 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Grina |
| Official Name | glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 (glutamate binding) [Source:MGI Symbol;Acc:MGI:1913418] |
| Ensembl ID | ENSMUSG00000022564 |
| Bio databases IDs | |
| Aliases | glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 (glutamate binding) |
| Synonyms | 1110025J15RIK, glutamate ionotropic receptor NMDA type subunit associated protein 1, glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 (glutamate binding), HNRGW, Lag, LFG1, NMDARA1, TMBIM3 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Grina often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Inhibitor of apoptosis-promoting Bax1
- BAX inhibitor (BI)-1/YccA-like protein family
- transmembrane domain
- ion channel binding
- Proline-rich protein
- protein binding
- ion channel
Pathways
Biological processes and signaling networks where the Grina gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- Amyotrophic Lateral Sclerosis Signaling
- Calcium Signaling
- Circadian Rhythm Signaling
- Dopamine-DARPP32 Feedback in cAMP Signaling
- Ephrin Receptor Signaling
- Glutamate Receptor Signaling
- Neuroinflammation Signaling Pathway
- Neuropathic Pain Signaling In Dorsal Horn Neurons
- nNOS Signaling in Neurons
- Opioid Signaling Pathway
- Reelin Signaling in Neurons
- Synaptic Long Term Potentiation
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- schizophrenia
regulates
- A4GALT
- globotriaosylceramide
- lactosylceramide
- TGOLN2
role in cell
- migration
- cell death
- accumulation in
- degradation in
- calcium homeostasis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Golgi Apparatus
- Endoplasmic Reticulum
- Golgi membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Grina gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- endoplasmic reticulum calcium ion homeostasis
- negative regulation of apoptotic signaling pathway
Cellular Component
Where in the cell the gene product is active
- membrane
- Golgi apparatus
- endoplasmic reticulum
Molecular Function
What the gene product does at the molecular level
- protein binding
- ion channel binding