Kcnj2 Gene Summary [Mouse]
Enables identical protein binding activity and inward rectifier potassium channel activity. Acts upstream of or within cardiac muscle cell action potential and magnesium ion transport. Predicted to be located in several cellular components, including T-tubule; dendritic spine; and intercalated disc. Predicted to be part of voltage-gated potassium channel complex. Predicted to be active in glutamatergic synapse and postsynaptic membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; heart; and sensory organ. Human ortholog(s) of this gene implicated in Andersen-Tawil syndrome; familial atrial fibrillation; familial periodic paralysis; and short QT syndrome. Orthologous to human KCNJ2 (potassium inwardly rectifying channel subfamily J member 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Kcnj2 |
| Official Name | potassium inwardly-rectifying channel, subfamily J, member 2 [Source:MGI Symbol;Acc:MGI:104744] |
| Ensembl ID | ENSMUSG00000041695 |
| Bio databases IDs | |
| Aliases | potassium inwardly-rectifying channel, subfamily J, member 2 |
| Synonyms | ATFB9, HHBIRK1, HHIRK1, IRK1, KIR2.1, LQT7, potassium inwardly rectifying channel subfamily J member 2, potassium inwardly-rectifying channel, subfamily J, member 2, SQT3 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Kcnj2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- phosphatidylinositol 4,5-biphosphate binding domain
- transmembrane pore region
- inward rectifier potassium channel
- protein binding
- pore domain
- identical protein binding
- Inward rectifier potassium channel N-terminal
- ion channel
- voltage-gated potassium channel
- cytoplasmic pore region
- cytoplasmic domain
- Inward rectifier potassium channel C-terminal domain
- phosphatidylinositol-4,5-bisphosphate binding
- Inward rectifier potassium channel transmembrane domain
- transmembrane domain
- tail domain
- Pka phosphorylation site
- PDZ binding motif
Pathways
Biological processes and signaling networks where the Kcnj2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- atrial fibrillation
- COVID-19
- diabetes mellitus
- non-insulin-dependent diabetes mellitus
- disorder of coronary artery
- congestive heart failure
- insulin resistance
- unstable angina
- angina pectoris
- coronary disease
role in cell
- proliferation
- growth
- hyperpolarization
- hyperpolarization in
- activity
- development
- firing
- silencing
- depolarization
- contraction
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- glutaminergic synapse
- intracellular compartment
- cell surface
- Golgi region
- intracellular space
- cellular membrane
- intercellular junctions
- postsynaptic membrane
- dendritic spines
- intercalated disks
- transverse tubules
- perikaryon
- dendrites
- detergent-soluble fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Kcnj2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of cardiac muscle cell action potential involved in contraction
- membrane repolarization involved in regulation of cardiac muscle cell action potential
- regulation of skeletal muscle contraction via membrane action potential
- membrane repolarization involved in regulation of action potential
- membrane depolarization involved in regulation of cardiac muscle cell action potential
- potassium ion transmembrane transport
- magnesium ion transport
- regulation of resting membrane potential
- regulation of cardiac muscle cell contraction
- relaxation of skeletal muscle
- regulation of membrane repolarization
- potassium ion transport
- cellular potassium ion homeostasis
- cellular response to mechanical stimulus
- protein homotetramerization
- regulation of ion transmembrane transport
- regulation of heart rate by cardiac conduction
- relaxation of cardiac muscle
Cellular Component
Where in the cell the gene product is active
- T-tubule
- postsynaptic membrane
- voltage-gated potassium channel complex
- membrane
- dendritic spine
- intercalated disc
- neuronal cell body
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- phosphatidylinositol-4,5-bisphosphate binding
- identical protein binding
- protein binding
- inward rectifier potassium channel activity
- voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization