Fmo1 Gene Summary [Mouse]
Enables hypotaurine monooxygenase activity. Involved in taurine biosynthetic process. Acts upstream of or within energy homeostasis; negative regulation of fatty acid oxidation; and xenobiotic metabolic process. Predicted to be located in endoplasmic reticulum membrane. Is expressed in brain; cortical renal tubule; late tubule; and testis. Orthologous to human FMO1 (flavin containing dimethylaniline monoxygenase 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Fmo1 |
| Official Name | flavin containing monooxygenase 1 [Source:MGI Symbol;Acc:MGI:1310002] |
| Ensembl ID | ENSMUSG00000040181 |
| Bio databases IDs | |
| Aliases | flavin containing monooxygenase 1 |
| Synonyms | flavin containing dimethylaniline monoxygenase 1, Flavin-containing monooxygenase, flavin containing monooxygenase 1, RFMO1A |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Fmo1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Rossmann-fold NAD(P)(+)-binding proteins
- NAD(P)-binding Rossmann-like domain
- monooxygenase
- enzyme
- Flavin-binding monooxygenase-like
- protein binding
- hypotaurine dehydrogenase
- FAD-NAD(P)-binding
- NADH2 or NADPH2 1 atom incorporation:oxygen oxidoreductase
- dimethylaniline monooxygenase (N-oxide-forming)
Pathways
Biological processes and signaling networks where the Fmo1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- early onset hypertension
- endometriosis
regulates
- fatty acid
- dapsone
- toxin peptide
- sulfamethoxazole
- phorate
- methiocarb
- taurine
- xenobiotic
- sulfur amino acid
- organic acid
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- endoplasmic reticulum membrane
- endoplasmic reticulum lumen
- microsome
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Fmo1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- organic acid metabolic process
- sulfur amino acid catabolic process
- negative regulation of fatty acid oxidation
- xenobiotic metabolic process
- NADPH oxidation
- energy homeostasis
- response to lipopolysaccharide
- taurine biosynthetic process
- toxin metabolic process
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- endoplasmic reticulum lumen
Molecular Function
What the gene product does at the molecular level
- NADP binding
- protein binding
- flavin adenine dinucleotide binding
- hypotaurine dehydrogenase activity
- monooxygenase activity
- trimethylamine monooxygenase activity
- N,N-dimethylaniline monooxygenase activity