Glp1r Gene Summary [Mouse]
Predicted to enable glucagon receptor activity; glucagon-like peptide 1 receptor activity; and peptide hormone binding activity. Involved in several processes, including learning or memory; positive regulation of blood pressure; and response to psychosocial stress. Acts upstream of or within with a positive effect on hormone secretion. Acts upstream of or within post-translational protein targeting to membrane, translocation. Predicted to be active in plasma membrane. Is expressed in several structures, including central nervous system; genitourinary system; gut; liver; and lung. Human ortholog(s) of this gene implicated in obesity. Orthologous to human GLP1R (glucagon like peptide 1 receptor). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Glp1r |
| Official Name | glucagon-like peptide 1 receptor [Source:MGI Symbol;Acc:MGI:99571] |
| Ensembl ID | ENSMUSG00000024027 |
| Bio databases IDs | |
| Aliases | glucagon-like peptide 1 receptor |
| Synonyms | Glip, GLP-1, GLP1Rc, GLP-1 receptor, Glpr1, Glucagon-Like Peptide 1 Receptor, RATGL1RCP |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Glp1r often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- Hormone receptor domain
- G-protein coupled peptide receptor
- 7 transmembrane receptor (Secretin family)
- signaling receptor activity
- intracellular domain
- protein binding
- peptide receptor
- seven-transmembrane G protein-coupled receptor superfamily
- polypeptide hormone binding
- transmembrane receptor
- phosphorylation site
Pathways
Biological processes and signaling networks where the Glp1r gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- obesity
- overweight disorder
- weight loss
- morbid obesity
- non-insulin-dependent diabetes mellitus
- polycystic ovary syndrome
- colorectal cancer
- acute coronary syndrome
- disorder of coronary artery
- acute ischemic stroke
role in cell
- phosphorylation in
- formation in
- apoptosis
- quantity
- expression in
- production in
- binding in
- proliferation
- activation
- differentiation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- caveosome
- cell surface
- cellular membrane
- nerve ending
- membrane rafts
- perikaryon
- axons
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Glp1r gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of heart contraction
- negative regulation of blood pressure
- cell surface receptor signaling pathway
- adenylate cyclase-activating G-protein coupled receptor signaling pathway
- hormone secretion
- positive regulation of blood pressure
- elevation of cytosolic calcium ion concentration
- learning or memory
- cellular response to glucagon stimulus
- posttranslational protein targeting to membrane, translocation
- activation of adenylate cyclase activity
- cAMP-mediated signaling
Cellular Component
Where in the cell the gene product is active
- membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- glucagon-like peptide 1 receptor activity
- protein binding
- transmembrane signaling receptor activity
- glucagon receptor activity
- peptide hormone binding