GRINA Gene Summary [Human]
Predicted to enable transmembrane transporter binding activity. Predicted to act upstream of or within endoplasmic reticulum calcium ion homeostasis and negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway. Predicted to be located in Golgi apparatus and endoplasmic reticulum. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | GRINA |
| Official Name | glutamate ionotropic receptor NMDA type subunit associated protein 1 [Source:HGNC Symbol;Acc:HGNC:4589] |
| Ensembl ID | ENSG00000178719 |
| Bio databases IDs | |
| Aliases | glutamate ionotropic receptor NMDA type subunit associated protein 1, transmembrane BAX inhibitor motif containing 3, lifeguard 1 |
| Synonyms | 1110025J15RIK, glutamate ionotropic receptor NMDA type subunit associated protein 1, glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 (glutamate binding), HNRGW, Lag, LFG1, NMDARA1, TMBIM3 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human GRINA often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Inhibitor of apoptosis-promoting Bax1
- BAX inhibitor (BI)-1/YccA-like protein family
- transmembrane domain
- ion channel binding
- Proline-rich protein
- protein binding
- ion channel
Pathways
Biological processes and signaling networks where the GRINA gene in human plays a role, providing insight into its function and relevance in health or disease.
- Amyotrophic Lateral Sclerosis Signaling
- Calcium Signaling
- Circadian Rhythm Signaling
- Dopamine-DARPP32 Feedback in cAMP Signaling
- Ephrin Receptor Signaling
- Glutamate Receptor Signaling
- Neuroinflammation Signaling Pathway
- Neuropathic Pain Signaling In Dorsal Horn Neurons
- nNOS Signaling in Neurons
- Opioid Signaling Pathway
- Reelin Signaling in Neurons
- Synaptic Long Term Potentiation
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- schizophrenia
role in cell
- migration
- cell death
- accumulation in
- degradation in
- calcium homeostasis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Golgi Apparatus
- Endoplasmic Reticulum
- Golgi membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human GRINA gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- endoplasmic reticulum calcium ion homeostasis
- negative regulation of apoptotic signaling pathway
Cellular Component
Where in the cell the gene product is active
- membrane
- Golgi apparatus
- endoplasmic reticulum
Molecular Function
What the gene product does at the molecular level
- protein binding
- ion channel binding