Gabrr2 Gene Summary [Mouse]
Enables GABA-A receptor activity. Acts upstream of or within gamma-aminobutyric acid signaling pathway and visual perception. Is active in intracellular vesicle. Is expressed in central nervous system; gut; male reproductive gland or organ; and retina. Human ortholog(s) of this gene implicated in autistic disorder. Orthologous to human GABRR2 (gamma-aminobutyric acid type A receptor subunit rho2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Gabrr2 |
| Official Name | gamma-aminobutyric acid (GABA) C receptor, subunit rho 2 [Source:MGI Symbol;Acc:MGI:95626] |
| Ensembl ID | ENSMUSG00000023267 |
| Bio databases IDs | |
| Aliases | gamma-aminobutyric acid (GABA) C receptor, subunit rho 2 |
| Synonyms | Gabar2, gamma-aminobutyric acid type A receptor subunit rho 2, RHO2, γ-aminobutyric acid type A receptor subunit rho 2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Gabrr2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- GABA-A receptor
- inhibitory extracellular ligand-gated ion channel
- transmembrane domain of Cys-loop neurotransmitter-gated ion channels
- channel/pore class transporter
- protein domain specific binding
- extracellular ligand-gated ion channel
- Cation transporter family protein
- protein binding
- ion channel
- anion channel
- neurotransmitter receptor
- LGIC_ECD
- Neurotransmitter-gated ion-channel transmembrane region
- Neurotransmitter-gated ion-channel ligand binding domain
- chloride channel
- ligand-gated ion channel
Pathways
Biological processes and signaling networks where the Gabrr2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- estazolam
- adinazolam
- diazepam
- flurazepam
- quazepam
- temazepam
- midazolam
- triazolam
- nitrazepam
- oxazepam
disease
- dementia
- depressive disorder
- schizophrenia
- anxiety disorder
- cancer
- cerebral palsy
- non-small cell lung cancer
- alcohol withdrawal syndrome
- pain
- arthritis
regulates
- chloride
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- intracellular membrane-bounded organelle
- cellular membrane
- vesicles
- synapse
- axons
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Gabrr2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of postsynaptic membrane potential
- regulation of membrane potential
- signal transduction
- synaptic transmission
- visual perception
- gamma-aminobutyric acid signaling pathway
Cellular Component
Where in the cell the gene product is active
- chloride channel complex
- postsynaptic membrane
- synapse
- neuron projection
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein domain specific binding
- neurotransmitter receptor activity
- GABA-A receptor activity
- chloride channel activity
- GABA-gated chloride ion channel activity