Sub1 Gene Summary [Mouse]
Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in RNA polymerase II promoter clearance; negative regulation of DNA metabolic process; and regulation of transcription by RNA polymerase II. Predicted to be located in nucleolus and nucleoplasm. Predicted to be part of transcription regulator complex. Predicted to be active in nucleus. Is expressed in several structures, including branchial arch; central nervous system; genitourinary system; limb; and sensory organ. Orthologous to human SUB1 (SUB1 regulator of transcription). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Sub1 |
| Official Name | SUB1 homolog, transcriptional regulator [Source:MGI Symbol;Acc:MGI:104811] |
| Ensembl ID | ENSMUSG00000022205 |
| Bio databases IDs | |
| Aliases | SUB1 homolog, transcriptional regulator |
| Synonyms | AI842364, LOC105374713, p14, P15, P9, PC4, Rpo2tc1, SUB1 homolog, transcriptional regulator, SUB1 regulator of transcription, TCP4 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Sub1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- transcription co-activator
- single-stranded DNA binding
- DNA binding domain
- nucleic acid binding
- double-stranded DNA binding
- transcription factor binding
- protein binding
- Transcriptional Coactivator p15 (PC4)
- sequence-specific DNA binding
- identical protein binding
- DNA helicase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- COVID-19
- Huntington disease
- motor dysfunction
- psoriasis
- metabolic syndrome X
- acute graft-vs-host disease
- breast carcinoma
- liver cancer
- organismal death
role in cell
- cell viability
- cell death
- apoptosis
- binding in
- number
- lengthening
- fragility
- accumulation in
- lengthening in
- poly(ADP-ribosyl)ation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- nucleoplasm
- nucleoli
- telomeres
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Sub1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- promoter clearance from RNA polymerase II promoter
- positive regulation of transcription initiation from RNA polymerase II promoter
- negative regulation of DNA metabolic process
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- transcription factor complex
- extracellular vesicular exosome
- nucleolus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- RNA binding
- protein binding
- transcription coactivator activity
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- single-stranded DNA binding