Slc25a27 Gene Summary [Mouse]
Predicted to enable chloride transmembrane transporter activity; protein homodimerization activity; and proton transmembrane transporter activity. Acts upstream of or within negative regulation of neuron apoptotic process. Located in mitochondrial inner membrane. Is expressed in central nervous system; neural retina; peripheral nervous system ganglion; and trigeminal nerve. Human ortholog(s) of this gene implicated in schizophrenia. Orthologous to human SLC25A27 (solute carrier family 25 member 27). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Slc25a27 |
| Official Name | solute carrier family 25, member 27 [Source:MGI Symbol;Acc:MGI:1921261] |
| Ensembl ID | ENSMUSG00000023912 |
| Bio databases IDs | |
| Aliases | solute carrier family 25, member 27 |
| Synonyms | 3632410G24RIK, 9430092A03RIK, D530043E16Rik, solute carrier family 25 member 27, solute carrier family 25, member 27, UCP 4 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Slc25a27 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- hydrogen ion transporter
- Mitochondrial carrier protein
- protein homodimerization
- chloride transporter
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
role in cell
- cell death
- apoptosis
- glycolysis in
- proliferation
- differentiation
- production in
- transmembrane potential
- pH
- generation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- apical compartment
- Mitochondria
- mitochondrial membrane
- mitochondrial inner membrane
- perikaryon
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Slc25a27 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to cold
- inner ear development
- negative regulation of mitochondrial membrane potential
- reduction of mitochondrial calcium ion concentration
- positive regulation of cell proliferation
- regulation of glucose import
- cellular triglyceride homeostasis
- negative regulation of neuron apoptotic process
Cellular Component
Where in the cell the gene product is active
- mitochondrial membrane
- apical part of cell
- mitochondrion
- neuronal cell body
- mitochondrial inner membrane
Molecular Function
What the gene product does at the molecular level
- protein homodimerization activity
- hydrogen ion transmembrane transporter activity
- transmembrane transporter activity
- chloride transmembrane transporter activity