Nit1 Gene Summary [Mouse]
Enables deaminated glutathione amidase activity. Involved in amide catabolic process. Located in mitochondrion. Is expressed in several structures, including colon; gonad; mammary gland; musculature; and spleen. Orthologous to human NIT1 (nitrilase 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Retained Intron |
| Official Symbol | Nit1 |
| Official Name | nitrilase 1 [Source:MGI Symbol;Acc:MGI:1350916] |
| Ensembl ID | ENSMUSG00000013997 |
| Bio databases IDs | |
| Aliases | nitrilase 1 |
| Synonyms | ESTM30, nitrilase 1, W57327 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Nit1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- nitrilase
- linear amide carbon-nitrogen bond hydrolase
- enzyme
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Nit1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cellular amide catabolic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- mitochondrion