Rel Gene Summary [Mouse]
Enables DNA-binding transcription factor activity. Acts upstream of or within positive regulation of DNA-templated transcription and positive regulation of interleukin-12 production. Located in cytoplasm and nucleus. Is expressed in central nervous system; eye; genitourinary system; heart; and spleen primordium. Human ortholog(s) of this gene implicated in immunodeficiency 92. Orthologous to human REL (REL proto-oncogene, NF-kB subunit). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rel |
| Official Name | reticuloendotheliosis oncogene [Source:MGI Symbol;Acc:MGI:97897] |
| Ensembl ID | ENSMUSG00000020275 |
| Bio databases IDs | |
| Aliases | reticuloendotheliosis oncogene |
| Synonyms | C-Rel, HIVEN86A, IMD92, REL proto-oncogene, NF-kB subunit, reticuloendotheliosis oncogene |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rel often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- transcription regulator
- dimerization domain
- DNA binding domain
- nucleic acid binding
- IPT
- Rel homology dimerization domain
- calmodulin binding domain
- transcription activation domain
- leucine zipper domain
- protein binding
- sequence-specific DNA binding
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- double-stranded DNA binding
- N-terminal sub-domain of the Rel homology domain (RHD)
- transcription factor activity
Pathways
Biological processes and signaling networks where the Rel gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- Acute Myeloid Leukemia Signaling
- Angiopoietin Signaling
- April Mediated Signaling
- Aryl Hydrocarbon Receptor Signaling
- B Cell Activating Factor Signaling
- BMP signaling pathway
- GADD45 Signaling
- HER-2 Signaling in Breast Cancer
- IL-17A Signaling in Airway Cells
- IL-17A Signaling in Fibroblasts
- IL-9 Signaling
- Induction of Apoptosis by HIV1
- JAK/Stat Signaling
- LPS-stimulated MAPK Signaling
- LXR/RXR Activation
- MIF Regulation of Innate Immunity
- MIF-mediated Glucocorticoid Regulation
- PEDF Signaling
- Rac Signaling
- Regulation of IL-2 Expression in Activated and Anergic T Lymphocytes
- Role of JAK1, JAK2 and TYK2 in Interferon Signaling
- Small Cell Lung Cancer Signaling
- TNFR1 Signaling
- TNFR2 Signaling
- Toll-like Receptor Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- rheumatoid arthritis
- cancer
- squamous cell lung cancer
- neoplastic cell transformation
- lymphomagenesis
- hematologic cancer
- lymphoid cancer
- hematological neoplasia
- lymphatic neoplasia
- immunodeficiency 92
role in cell
- expression in
- transactivation in
- conversion
- binding in
- apoptosis
- growth
- cell death
- differentiation
- proliferation
- quantity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- Cytoplasm
- cytosol
- nucleoplasm
- chromatin
- cytoplasmic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Rel gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to cytokine stimulus
- negative regulation of gene expression
- inflammatory response
- innate immune response
- positive regulation of I-kappaB kinase/NF-kappaB cascade
- NIK/NF-kappaB cascade
- cellular response to stress
- positive regulation of transcription from RNA polymerase II promoter
- I-kappaB kinase/NF-kappaB cascade
- negative regulation of interferon-beta production
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- cytosol
- NF-kappaB complex
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- sequence-specific DNA binding transcription factor activity
- protein binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- sequence-specific DNA binding RNA polymerase II transcription factor activity