Arhgap28 Gene Summary [Mouse]
Predicted to enable GTPase activator activity. Acts upstream of or within negative regulation of stress fiber assembly. Predicted to be located in cell junction and nucleoplasm. Predicted to be active in cytoplasm. Is expressed in lower leg bone. Human ortholog(s) of this gene implicated in allergic disease. Orthologous to human ARHGAP28 (Rho GTPase activating protein 28). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Arhgap28 |
| Official Name | Rho GTPase activating protein 28 [Source:MGI Symbol;Acc:MGI:2147003] |
| Ensembl ID | ENSMUSG00000024043 |
| Bio databases IDs | |
| Aliases | Rho GTPase activating protein 28 |
| Synonyms | AU044757, AW550892, E130310N06, RGD1559882, Rho GTPase activating protein 28 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Arhgap28 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RhoGAP domain
- GTPase activator
- GTPase-activator protein for Rho-like GTPases
- RhoGAP
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cell junction
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Arhgap28 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of actin filament polymerization
- negative regulation of stress fiber assembly
- signal transduction
- regulation of small GTPase mediated signal transduction
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- cytosol
- cell junction
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- GTPase activator activity