Mtnr1a Gene Summary [Mouse]
Predicted to enable hormone binding activity and melatonin receptor activity. Predicted to be involved in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway and negative regulation of insulin secretion. Predicted to act upstream of or within circadian rhythm. Predicted to be located in neuronal cell body. Predicted to be part of receptor complex. Predicted to be active in plasma membrane. Is expressed in several structures, including adrenal gland; alimentary system; brain; liver and biliary system; and reproductive system. Orthologous to human MTNR1A (melatonin receptor 1A). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Mtnr1a |
| Official Name | melatonin receptor 1A [Source:MGI Symbol;Acc:MGI:102967] |
| Ensembl ID | ENSMUSG00000054764 |
| Bio databases IDs | |
| Aliases | melatonin receptor 1A |
| Synonyms | MEL-1A-R, melatonin receptor 1A, MelR, MR, MT1, MT1 receptor |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Mtnr1a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- hormone binding
- Cholecystokinin A receptor, N-terminal
- melatonin receptor
- transmembrane domain
- 7 transmembrane receptor (rhodopsin family)
- tail domain
- protein binding
- seven-transmembrane G protein-coupled receptor superfamily
Pathways
Biological processes and signaling networks where the Mtnr1a gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- obesity
- fatigue
- COVID-19
- asthenia
- schizophrenia
- migraines
- locally advanced oral squamous cell carcinoma
- dyssomnia
- brain damage
role in cell
- expression in
- number
- abnormal morphology
- function
- recruitment in
- activation in
- degeneration
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
- Mitochondria
- perikaryon
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Mtnr1a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
- mating behavior
- G-protein coupled receptor signaling pathway
- G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
- circadian rhythm
Cellular Component
Where in the cell the gene product is active
- receptor complex
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- G-protein coupled receptor activity
- protein binding
- organic cyclic compound binding
- hormone binding
- melatonin receptor activity