Gli1

Enables several functions, including DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and microtubule binding activity. Involved in positive regulation of DNA-templated transcription and regulation of osteoblast differentiation. Acts upstream of or within several processes, including central nervous system development; liver regeneration; and regionalization. Located in axoneme and nucleus. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; long bone; and sensory organ. Human ortholog(s) of this gene implicated in gallbladder cancer and preaxial polydactyly I. Orthologous to human GLI1 (GLI family zinc finger 1). [provided by Alliance of Genome Resources, Jul 2025]

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Gli1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.

Biological processes and signaling networks where the Gli1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.

Describes the biological processes, cellular components, and molecular functions associated with the mouse Gli1 gene, providing context for its role in the cell.