Abca3 Gene Summary [Mouse]
Predicted to enable ABC-type xenobiotic transporter activity; ATP hydrolysis activity; and phosphatidylcholine transporter activity. Involved in several processes, including glycerophospholipid metabolic process; phospholipid homeostasis; and surfactant homeostasis. Located in alveolar lamellar body membrane. Is expressed in several structures, including genitourinary system; gut; hemolymphoid system; nervous system; and respiratory system. Used to study pulmonary alveolar proteinosis. Human ortholog(s) of this gene implicated in pulmonary alveolar proteinosis. Orthologous to human ABCA3 (ATP binding cassette subfamily A member 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Retained Intron |
| Official Symbol | Abca3 |
| Official Name | ATP-binding cassette, sub-family A (ABC1), member 3 [Source:MGI Symbol;Acc:MGI:1351617] |
| Ensembl ID | ENSMUSG00000024130 |
| Bio databases IDs | |
| Aliases | ATP-binding cassette, sub-family A (ABC1), member 3 |
| Synonyms | 1810036E22Rik, Abc3, ABC-C, ATP-binding cassette, sub-family A member 3 |
| Species | Mouse, Mus musculus |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Abca3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- phospholipid transporter
- nickel import ATP-binding protein NikD
- daunorubicin resistance ABC transporter ATP-binding subunit
- nitrate transport ATP-binding subunits C and D
- ATPase
- heme ABC exporter, ATP-binding protein CcmA
- lipid transporter
- phosphonate C-P lyase system protein PhnK
- LPS export ABC transporter ATP-binding protein
- phosphatidylcholine transporter
- gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit
- xenobiotic-transporting ATPase
- nickel import ATP-binding protein NikE
- ABC transporter
- P-loop containing Nucleoside Triphosphate Hydrolases
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- atelectasis
- acute respiratory failure
- cyanosis
- respiratory failure
- bleeding
- dyspnea
- congestion
regulates
- phosphatidylcholine
- SFTPB
- lipid
- phospholipid
- 30:0 phosphatidylcholine
- 30:1 phosphatidylcholine
- palmitic acid
- phosphatidylethanolamine
- 32:0 phosphatidylcholine
- 34:3 phosphatidylglycerol
role in cell
- growth
- quantity
- loss
- morphology
- assembly
- biogenesis in
- lack
- abnormal morphology
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytoplasmic vesicle membrane
- Plasma Membrane
- secretory granule membrane
- alveolar epithelial lamellar bodies
- late endosomes