Pigf Gene Summary [Mouse]
Predicted to enable mannose-ethanolamine phosphotransferase activity. Involved in GPI anchor biosynthetic process. Located in endoplasmic reticulum membrane. Is expressed in several structures, including alimentary system; brain; respiratory system; sensory organ; and urinary system. Orthologous to human PIGF (phosphatidylinositol glycan anchor biosynthesis class F). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pigf |
| Official Name | phosphatidylinositol glycan anchor biosynthesis, class F [Source:MGI Symbol;Acc:MGI:99462] |
| Ensembl ID | ENSMUSG00000024145 |
| Bio databases IDs | |
| Aliases | phosphatidylinositol glycan anchor biosynthesis, class F |
| Synonyms | LOC681973, OORS, phosphatidylinositol glycan anchor biosynthesis class F, phosphatidylinositol glycan anchor biosynthesis, class F, Phosphatidylinositol glycan class f |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Pigf often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- GPI biosynthesis protein family Pig-F
- substituted phosphate group transferase
- enzyme
- protein binding
- ethanolaminephosphotransferase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- preeclampsia
- organismal death
- onychodystrophy, osteodystrophy, impaired intellectual development, and seizures syndrome
- polycystic ovary syndrome
role in cell
- proliferation
- migration
- activation in
- tyrosine phosphorylation in
- autophagy in
- dipeptide repeat protein sensitivity
- autophagy
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Endoplasmic Reticulum
- endoplasmic reticulum membrane
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Pigf gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- GPI anchor biosynthetic process
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- mannose-ethanolamine phosphotransferase activity
- ethanolaminephosphotransferase activity