Wdhd1 Gene Summary [Mouse]
Enables RNA binding activity; RNA polymerase binding activity; and chromatin binding activity. Acts upstream of or within RNA processing; pericentric heterochromatin organization; and regulation of chromosome organization. Located in chromosome, centromeric region. Is expressed in several structures, including brain; genitourinary system; hemolymphoid system; liver; and submandibular gland primordium. Human ortholog(s) of this gene implicated in cholangiocarcinoma. Orthologous to human WDHD1 (WD repeat and HMG-box DNA binding protein 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Wdhd1 |
| Official Name | WD repeat and HMG-box DNA binding protein 1 [Source:MGI Symbol;Acc:MGI:2443514] |
| Ensembl ID | ENSMUSG00000037572 |
| Bio databases IDs | |
| Aliases | WD repeat and HMG-box DNA binding protein 1 |
| Synonyms | A630092E18, AND-1, CHTF4, CTF4, D630024B06RIK, WD repeat and HMG-box DNA binding protein 1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Wdhd1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- high mobility group (HMG)-box domain superfamily
- Minichromosome loss protein, Mcl1, middle region
- WD domain, G-beta repeat
- enzyme binding
- chromatin binding
- WD40
- protein binding
- SepB domain
- DNA binding
- RNA binding
- Anaphase-promoting complex subunit 4 WD40 domain
- WD-like repeat
- WD40 repeats
- high mobility group
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- chordoma
- bone cancer
- colorectal carcinomagenesis
- lung adenocarcinoma
- lung adenocarcinoma formation
- Parkinson disease
- cleft lip
- colorectal carcinoma
role in cell
- binding in
- ubiquitination in
- degradation in
- number
- organization
- misalignment
- association
- misalignment in
- stabilization in
- association in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- nucleoplasm
- centromeres
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Wdhd1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- DNA repair
- DNA-dependent DNA replication
- mitotic cell cycle
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- nuclear replication fork
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- protein binding
- chromatin binding