Slc23a1 Gene Summary [Mouse]
Enables L-ascorbate:sodium symporter activity; L-ascorbic acid transmembrane transporter activity; and urate transmembrane transporter activity. Involved in L-ascorbic acid transmembrane transport; brain development; and lung development. Located in basal plasma membrane and cytoplasm. Is expressed in several structures, including alimentary system; liver; and urinary system. Orthologous to human SLC23A1 (solute carrier family 23 member 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Slc23a1 |
| Official Name | solute carrier family 23 (nucleobase transporters), member 1 [Source:MGI Symbol;Acc:MGI:1341903] |
| Ensembl ID | ENSMUSG00000024354 |
| Bio databases IDs | |
| Aliases | solute carrier family 23 (nucleobase transporters), member 1 |
| Synonyms | D18Ucla2, NCBT1, SLC23A2, solute carrier family 23 member 1, solute carrier family 23 (nucleobase transporters), member 1, SVCT1, YSPL3 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Slc23a1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Permease family
- nucleobase transporter
- uracil-xanthine permease
- xanthine permease
- sodium ion transporter
- L-ascorbate transporter
- protein binding
- organic anion transporter
- urate transporter
- L-ascorbate:sodium symporter
- transporter
Pathways
Biological processes and signaling networks where the Slc23a1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- bleeding
- renal clear cell adenocarcinoma
- renal clear cell cancer
- aminoaciduria
regulates
- vitamin
- ascorbic acid
- Na+
- dehydroascorbic acid
- nitrogenous base
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- organelle
- Cytoplasm
- cell surface
- cellular membrane
- apical cell surfaces
- apical membrane
- basal membrane
- cytoplasmic vesicles
- brush border
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Slc23a1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- sodium ion transport
- nucleobase transport
- L-ascorbic acid transport
- dehydroascorbic acid transport
- sodium ion transmembrane transport
- L-ascorbic acid metabolic process
- urate transport
- brain development
- response to toxin
- lung development
Cellular Component
Where in the cell the gene product is active
- intracellular organelle
- basal plasma membrane
- extracellular vesicular exosome
- cytoplasm
- apical plasma membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- urate transmembrane transporter activity
- dehydroascorbic acid transporter activity
- L-ascorbate:sodium symporter activity
- sodium ion transmembrane transporter activity
- L-ascorbic acid transporter activity
- nucleobase transmembrane transporter activity
- transporter activity