Mtus2 Gene Summary [Mouse]
Predicted to enable microtubule binding activity and protein homodimerization activity. Predicted to be located in intercellular bridge and microtubule cytoskeleton. Predicted to be active in nucleus. Predicted to colocalize with centrosome and cytoplasmic microtubule. Is expressed in several structures, including central nervous system; eye; heart; peripheral nervous system; and respiratory system. Orthologous to human MTUS2 (microtubule associated scaffold protein 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Mtus2 |
| Official Name | microtubule associated tumor suppressor candidate 2 [Source:MGI Symbol;Acc:MGI:1915388] |
| Ensembl ID | ENSMUSG00000029651 |
| Bio databases IDs | |
| Aliases | microtubule associated tumor suppressor candidate 2 |
| Synonyms | 5730592G18Rik, A730013O20Rik, C130038G02Rik, CAZIP, Gm763, ICIS, KIAA0774, microtubule associated scaffold protein 2, microtubule associated tumor suppressor candidate 2, microtubule associated tumour suppressor candidate 2, mKIAA0774, RGD1562533, TIP150 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Mtus2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SPEC
- Coiled-coil region of CCDC155 or KASH
- Septum formation initiator
- Tropomyosin like
- Ezrin/radixin/moesin, alpha-helical domain
- Coiled-coiled domain of autophagy-related 16 (Atg16) family proteins
- protein binding
- Bin/Amphiphysin/Rvs domain
- microtubule binding
- Tropomyosin
- Family with sequence similarity 184, A and B
- Growth-arrest specific micro-tubule binding
- protein homodimerization
- Intermediate filament protein
- Cell division protein ZapB
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- colorectal cancer
- fibromuscular dysplasia
- schizophrenia
- hypertension
- breast cancer
- idiopathic scoliosis
- ovarian carcinoma
- epithelial ovarian cancer
- luminal A breast carcinoma
- luminal A breast cancer
role in cell
- attachment
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- microtubule cytoskeleton
- centrosome
- cytoplasmic bridges
- cytoplasmic microtubule
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Mtus2 gene, providing context for its role in the cell.
Cellular Component
Where in the cell the gene product is active
- nucleus
- intercellular bridge
- microtubule cytoskeleton
- centrosome
- cytoplasm
- cytoplasmic microtubule
Molecular Function
What the gene product does at the molecular level
- protein homodimerization activity
- protein binding
- microtubule binding