SLC23A1 Gene Summary [Human]

The absorption of vitamin C into the body and its distribution to organs requires two sodium-dependent vitamin C transporters. This gene encodes one of the two transporters. The encoded protein is active in bulk vitamin C transport involving epithelial surfaces. Previously, this gene had an official symbol of SLC23A2. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]

Details

Type
Protein Coding
Official Symbol
SLC23A1
Official Name
solute carrier family 23 member 1 [Source:HGNC Symbol;Acc:HGNC:10974]
Ensembl ID
ENSG00000170482
Bio databases IDs NCBI: 9963 Ensembl: ENSG00000170482
Aliases solute carrier family 23 member 1
Synonyms D18Ucla2, NCBT1, SLC23A2, solute carrier family 23 member 1, solute carrier family 23 (nucleobase transporters), member 1, SVCT1, YSPL3
Species
Human, Homo sapiens
OrthologiesMouseRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SLC23A1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • Permease family
  • nucleobase transporter
  • uracil-xanthine permease
  • xanthine permease
  • sodium ion transporter
  • L-ascorbate transporter
  • protein binding
  • organic anion transporter
  • urate transporter
  • L-ascorbate:sodium symporter
  • transporter

Pathways

Biological processes and signaling networks where the SLC23A1 gene in human plays a role, providing insight into its function and relevance in health or disease.

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • bleeding
  • renal clear cell adenocarcinoma
  • renal clear cell cancer
  • aminoaciduria
regulated by
  • IL4
  • CD40LG
  • tetradecanoylphorbol acetate
  • Gstp1 (includes others)
  • CTNNB1
  • pirinixic acid
  • 2,4,5,2',4',5'-hexachlorobiphenyl
  • GW7647
regulates
  • vitamin
  • ascorbic acid
  • Na+
  • dehydroascorbic acid
  • nitrogenous base

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Plasma Membrane
  • organelle
  • Cytoplasm
  • cell surface
  • cellular membrane
  • apical cell surfaces
  • apical membrane
  • basal membrane
  • cytoplasmic vesicles
  • brush border

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the human SLC23A1 gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • sodium ion transport
  • nucleobase transport
  • L-ascorbic acid transport
  • dehydroascorbic acid transport
  • sodium ion transmembrane transport
  • L-ascorbic acid metabolic process
  • urate transport
  • brain development
  • response to toxin
  • lung development

Cellular Component

Where in the cell the gene product is active
  • intracellular organelle
  • basal plasma membrane
  • extracellular vesicular exosome
  • cytoplasm
  • apical plasma membrane
  • plasma membrane

Molecular Function

What the gene product does at the molecular level
  • protein binding
  • urate transmembrane transporter activity
  • dehydroascorbic acid transporter activity
  • L-ascorbate:sodium symporter activity
  • sodium ion transmembrane transporter activity
  • L-ascorbic acid transporter activity
  • nucleobase transmembrane transporter activity
  • transporter activity

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.