Rpp21 Gene Summary [Mouse]
Predicted to enable ribonuclease P RNA binding activity. Predicted to contribute to ribonuclease P activity. Predicted to be involved in tRNA 5'-leader removal. Predicted to be located in nucleolus. Predicted to be part of nucleolar ribonuclease P complex. Orthologous to human RPP21 (ribonuclease P/MRP subunit p21). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rpp21 |
| Official Name | ribonuclease P 21 subunit [Source:MGI Symbol;Acc:MGI:1914926] |
| Ensembl ID | ENSMUSG00000024446 |
| Bio databases IDs | |
| Aliases | ribonuclease P 21 subunit |
| Synonyms | 0610037N01Rik, C6orf135, CAT60, Flj22638, ribonuclease P 21 subunit, ribonuclease P/MRP subunit p21 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rpp21 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ribonuclease P
- enzyme
- protein binding
- RNAse P Rpr2/Rpp21/SNM1 subunit domain
- RNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Rpp21 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- tRNA processing
- response to xenobiotic stimulus
- tRNA 5'-leader removal
Cellular Component
Where in the cell the gene product is active
- multimeric ribonuclease P complex
- nucleolar ribonuclease P complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ribonuclease P activity
- protein binding
- metal ion binding
- ribonuclease P RNA binding