Rnaseh2c Gene Summary [Mouse]

Predicted to be involved in RNA catabolic process. Part of ribonuclease H2 complex. Is expressed in several structures, including hemolymphoid system gland; retina nuclear layer; skin; telencephalon; and testis. Human ortholog(s) of this gene implicated in Aicardi-Goutieres syndrome. Orthologous to human RNASEH2C (ribonuclease H2 subunit C). [provided by Alliance of Genome Resources, Jul 2025]

Details

Type
Protein Coding
Official Symbol
Rnaseh2c
Official Name
ribonuclease H2, subunit C [Source:MGI Symbol;Acc:MGI:1915459]
Ensembl ID
ENSMUSG00000024925
Bio databases IDs NCBI: 68209 Ensembl: ENSMUSG00000024925
Aliases ribonuclease H2, subunit C
Synonyms 1500026D16Rik, AGS3, AYP1, ribonuclease H2 subunit C, ribonuclease H2, subunit C
Species
Mouse, Mus musculus
OrthologiesHumanRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rnaseh2c often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • Ribonuclease H2C
  • protein binding

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • Aicardi-Goutieres syndrome 3
  • hereditary disorder
  • Aicardi-Goutieres syndrome
  • RNASEH2C-related type 1 interferonopathy
regulated by
role in cell
  • cell death

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Unknown

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the mouse Rnaseh2c gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • mismatch repair
  • RNA catabolic process

Cellular Component

Where in the cell the gene product is active
  • nucleus
  • ribonuclease H2 complex

Molecular Function

What the gene product does at the molecular level
  • protein binding