Fen1 Gene Summary [Mouse]
Enables DNA binding activity; metal ion binding activity; and nuclease activity. Acts upstream of or within DNA repair and DNA replication. Predicted to be located in mitochondrion; nucleolus; and nucleoplasm. Predicted to be part of protein-containing complex. Predicted to be active in nucleus. Predicted to colocalize with chromosome, telomeric region. Is expressed in several structures, including brain; genitourinary system; liver; lung; and spleen. Orthologous to human FEN1 (flap structure-specific endonuclease 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Fen1 |
| Official Name | flap structure specific endonuclease 1 [Source:MGI Symbol;Acc:MGI:102779] |
| Ensembl ID | ENSMUSG00000024742 |
| Bio databases IDs | |
| Aliases | flap structure specific endonuclease 1 |
| Synonyms | flap structure-specific endonuclease 1, MF1, RAD2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Fen1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- flap structure-specific endonuclease
- PCNA binding domain
- 5'-3' exonuclease
- catalytic domain
- Xeroderma pigmentosum G I-region
- XPG I-region
- enzyme
- flap endonuclease
- double-stranded DNA specific exodeoxyribonuclease
- XPG N-terminal domain
- protein binding
- Helix-hairpin-helix class 2 (Pol1 family) motifs
- magnesium ion binding
- DNA binding
- endonuclease
- H3TH_StructSpec-5'-nucleases
- damaged DNA binding
- ribonuclease H
- exonuclease
- double-stranded DNA binding
- Xeroderma pigmentosum G N-region
- manganese ion binding
- loop domain
- PIN (PilT N terminus) domain: Superfamily
Pathways
Biological processes and signaling networks where the Fen1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Waldenström macroglobulinemia
- neoplasia
- cancer
- epithelial cancer
- colon cancer
- castration refractory prostate carcinoma
- castration refractory prostate cancer
- mammary neoplasm
- gastrointestinal neoplasia
- organismal death
role in cell
- apoptosis
- function
- expression in
- quantity
- migration
- proliferation
- growth
- number
- damage in
- cell death
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- Mitochondria
- nucleoplasm
- nucleoli
- telomeres
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Fen1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- nucleic acid metabolic process
- DNA repair
- UV protection
- DNA replication
- telomere maintenance via semi-conservative replication
- double-strand break repair via homologous recombination
- base-excision repair, gap-filling
- DNA replication, removal of RNA primer
- memory
- positive regulation of sister chromatid cohesion
- double-strand break repair
Cellular Component
Where in the cell the gene product is active
- chromosome, telomeric region
- nucleus
- mitochondrion
- membrane
- macromolecular complex
- nucleolus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- 5'-flap endonuclease activity
- double-stranded DNA binding
- damaged DNA binding
- 5'-3' exonuclease activity
- magnesium ion binding
- DNA binding
- ribonuclease H activity
- double-stranded DNA specific exodeoxyribonuclease activity
- protein binding
- exonuclease activity
- flap endonuclease activity
- endonuclease activity
- manganese ion binding