Dlx6 Gene Summary [Mouse]
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within several processes, including embryonic morphogenesis; positive regulation of epithelial cell proliferation; and roof of mouth development. Predicted to be located in nucleus. Is expressed in several structures, including alimentary system; brain; branchial arch; limb; and sensory organ. Used to study split hand-foot malformation 1. Orthologous to human DLX6 (distal-less homeobox 6). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Dlx6 |
| Official Name | distal-less homeobox 6 [Source:MGI Symbol;Acc:MGI:101927] |
| Ensembl ID | ENSMUSG00000029754 |
| Bio databases IDs | |
| Aliases | distal-less homeobox 6 |
| Synonyms | distal-less homeobox 6, LOC100365183, RGD1561539 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Dlx6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- transcription regulator
- double-stranded DNA binding
- sequence-specific DNA binding
- transcription factor activity
- homeodomain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- transitional cell bladder cancer
- squamous cell lung cancer
- lung squamous cell carcinoma
- rectum cancer
- renal clear cell adenocarcinoma
- androgenic alopecia
- lung adenocarcinoma
- lung adenocarcinoma formation
- urothelial bladder carcinoma
- head and neck squamous cell carcinoma
role in cell
- proliferation
- differentiation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Dlx6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- embryo development
- head development
- palate development
- nervous system development
- anatomical structure formation involved in morphogenesis
- regulation of transcription from RNA polymerase II promoter
- epithelial cell differentiation
- embryonic limb morphogenesis
- skeletal system development
- inner ear morphogenesis
- cell differentiation
- positive regulation of epithelial cell proliferation
Cellular Component
Where in the cell the gene product is active
- nucleus
- chromatin
Molecular Function
What the gene product does at the molecular level
- sequence-specific DNA binding transcription factor activity
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity