Prdx5 Gene Summary [Mouse]
This gene encodes a member of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. The encoded protein plays an antioxidant protective role in different tissues under normal conditions and during inflammatory processes. The use of alternate transcription start sites may result in use of alternate in-frame translation start codons that generate alternate isoforms that are targeted to the mitochondrion or peroxisome/cytoplasm. [provided by RefSeq, Nov 2017]
Details
| Type | Retained Intron |
| Official Symbol | Prdx5 |
| Official Name | peroxiredoxin 5 [Source:MGI Symbol;Acc:MGI:1859821] |
| Ensembl ID | ENSMUSG00000024953 |
| Bio databases IDs | |
| Aliases | peroxiredoxin 5 |
| Synonyms | ACR1, AOEB166, AOPP, B166, HEL-S-55, Peroxiredoxin 5, PLP, PMP20, PRDX6, PRXV, SBBI10, THIOREDOXIN PEROXIDASE 5 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Prdx5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- nucleic acid binding
- caspase inhibitor activity
- thioredoxin peroxidase
- enzyme
- antioxidant enzyme
- protein binding
- receptor binding
- sequence-specific DNA binding
- identical protein binding
- peroxidase
- peroxidase (miscellaneous)
- double-stranded DNA binding
- Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
- AhpC/TSA family
Pathways
Biological processes and signaling networks where the Prdx5 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- breast cancer
- adenomyosis
- insulin resistance
- obesity
- colorectal cancer
- cold thyroid nodule
- morbid obesity
- autosomal dominant polycystic kidney disease
- weight gain
- complete testicular feminization syndrome
role in cell
- apoptosis
- expression in
- phosphorylation in
- acetylation in
- quantity
- formation
- formation by
- response by
- formation in
- autophagy in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- peroxisomal matrix
- intracellular membrane-bounded organelle
- perinuclear region
- Nucleus
- Mitochondria
- cytosol
- mitochondrial matrix
- cytoplasmic vesicles
- peroxisomes
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Prdx5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to oxidative stress
- inflammatory response
- negative regulation of transcription from RNA polymerase III promoter
- negative regulation of apoptotic process
- cellular response to oxidative stress
- cell redox homeostasis
- cellular response to reactive oxygen species
- hydrogen peroxide catabolic process
Cellular Component
Where in the cell the gene product is active
- peroxisomal matrix
- peroxisome
- nucleus
- extracellular space
- extracellular vesicular exosome
- perinuclear region of cytoplasm
- cytoplasm
- mitochondrial matrix
- intracellular membrane-bounded organelle
- mitochondrion
- cytoplasmic vesicle
- cytosol
Molecular Function
What the gene product does at the molecular level
- peroxidase activity
- protein binding
- thioredoxin peroxidase activity
- RNA polymerase III regulatory region DNA binding
- cysteine-type endopeptidase inhibitor activity involved in apoptotic process