Ube2h Gene Summary [Mouse]

Enables ubiquitin conjugating enzyme activity. Acts upstream of or within proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and liver and biliary system. Orthologous to human UBE2H (ubiquitin conjugating enzyme E2 H). [provided by Alliance of Genome Resources, Jul 2025]

Details

Type
Protein Coding
Official Symbol
Ube2h
Official Name
ubiquitin-conjugating enzyme E2H [Source:MGI Symbol;Acc:MGI:104632]
Ensembl ID
ENSMUSG00000039159
Bio databases IDs NCBI: 22214 Ensembl: ENSMUSG00000039159
Aliases ubiquitin-conjugating enzyme E2H
Synonyms 1500009C23Rik, E2-20K, E2h, E2H10, FLJ20866, GID3, LOC100361890, UBC8, UBCH, UBCH2, ubiquitin-conjugating enzyme E2H
Species
Mouse, Mus musculus
OrthologiesHumanRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ube2h often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • Ubiquitin-conjugating enzyme
  • ubiquitin conjugating enzyme
  • ubiquitin-protein transferase activity
  • UBCc_UEV
  • enzyme
  • protein binding

Pathways

Biological processes and signaling networks where the Ube2h gene in mouse plays a role, providing insight into its function and relevance in health or disease.

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • rheumatoid arthritis
  • peripheral arterial disease
  • infection by HIV-1
  • androgenic alopecia
  • alcoholic liver disease
regulated by
regulates
role in cell
  • ubiquitination in
  • degradation in

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Cytoplasm
  • cytosol

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the mouse Ube2h gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • proteasomal ubiquitin-dependent protein catabolic process
  • protein K11-linked ubiquitination
  • protein K48-linked ubiquitination
  • protein polyubiquitination
  • ubiquitin-dependent protein catabolic process

Cellular Component

Where in the cell the gene product is active
  • nucleus
  • cytosol

Molecular Function

What the gene product does at the molecular level
  • ATP binding
  • ubiquitin-protein ligase activity
  • protein binding

Gene-Specific Assays for Results You Can Trust

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