Cyp2c39 Gene Summary [Mouse]
Enables arachidonate 11,12-epoxygenase activity. Involved in arachidonate metabolic process. Predicted to be located in plasma membrane. Predicted to be active in cytoplasm and intracellular membrane-bounded organelle. Is expressed in liver. Human ortholog(s) of this gene implicated in several diseases, including Plasmodium falciparum malaria; carcinoma (multiple); eosinophilic esophagitis; glucose metabolism disease (multiple); and heroin dependence. Orthologous to human CYP2C18 (cytochrome P450 family 2 subfamily C member 18); CYP2C19 (cytochrome P450 family 2 subfamily C member 19); and CYP2C9 (cytochrome P450 family 2 subfamily C member 9). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cyp2c39 |
| Official Name | cytochrome P450, family 2, subfamily c, polypeptide 39 [Source:MGI Symbol;Acc:MGI:1306818] |
| Ensembl ID | ENSMUSG00000025003 |
| Bio databases IDs | |
| Aliases | cytochrome P450, family 2, subfamily c, polypeptide 39 |
| Synonyms | Ah-2, Ahh-1, AHOH, AHOHase, AI159681, Cyp2c, Cyp2c38, Cyp2c39, Cyp2c7, Cyp2c9, CYPIIC39, Cytochrome p450, cytochrome P450, family 2, subfamily c, polypeptide 29, cytochrome P450, family 2, subfamily c, polypeptide 38, cytochrome P450, family 2, subfamily c, polypeptide 39, cytochrome P450, family 2, subfamily c, polypeptide 7, LOC100361347, LOC100911552, LOC100911791, LOC103691183, LOC639008, P450-2C |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cyp2c39 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- arachidonic acid 11,12-epoxygenase
- arachidonic acid 14,15-epoxygenase
- oxidoreductase
- enzyme binding
- enzyme
- steroid hydroxylase
- heme binding
- CH2 group oxidoreductase
- arachidonic acid epoxygenase
- cytochrome P450 (CYP) superfamily
- Cytochrome P450
- reduced flavin or flavoprotein:oxygen oxidoreductase
- retinoic acid 4-hydroxylase
- monooxygenase
Pathways
Biological processes and signaling networks where the Cyp2c39 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
regulates
- tolbutamide
- arachidonic acid
- tretinoin
- diclofenac
- 5-hydroxy-4-(glutathion-S-yl)diclofenac
- 5-hydroxy-6-(glutathion-S-yl)diclofenac
- Cyp2c29 (includes others)
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- interchromatin granule cluster fractions
- intracellular membrane-bounded organelle
- Plasma Membrane
- Endoplasmic Reticulum
- endoplasmic reticulum membrane
- microsome