Fech Gene Summary [Mouse]
Enables several functions, including ferrochelatase activity; heme binding activity; and iron-responsive element binding activity. Involved in heme A biosynthetic process; heme B biosynthetic process; and heme O biosynthetic process. Acts upstream of or within several processes, including multicellular organismal-level iron ion homeostasis; regulation of protein metabolic process; and very-low-density lipoprotein particle assembly. Located in mitochondrial inner membrane. Is active in mitochondrial matrix. Is expressed in several structures, including choroid plexus; heart; integumental system; liver and biliary system; and respiratory system. Used to study erythropoietic protoporphyria. Human ortholog(s) of this gene implicated in cutaneous porphyria and erythropoietic protoporphyria. Orthologous to human FECH (ferrochelatase). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Fech |
| Official Name | ferrochelatase [Source:MGI Symbol;Acc:MGI:95513] |
| Ensembl ID | ENSMUSG00000024588 |
| Bio databases IDs | |
| Aliases | ferrochelatase |
| Synonyms | EPP, EPP1, FCE, fch, Fcl, ferrochelatase |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Fech often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ferrous iron binding
- Chelatase_Class_II
- ferrochelatase
- protein homodimerization
- iron-sulfur cluster domain
- iron ion binding
- enzyme
- iron-responsive element binding
- protein binding
- heme binding
- identical protein binding
- tetrapyrrole binding
Pathways
Biological processes and signaling networks where the Fech gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- gastric cancer
- erythropoietic protoporphyria type 1
- colorectal cancer
- erythropoietic protoporphyria
- myopathy with exercise intolerance Swedish type
- retinal neovascularization
role in cell
- proliferation
- differentiation
- survival
- outgrowth
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- mitochondrial matrix
- mitochondrial inner membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Fech gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- generation of precursor metabolites and energy
- multicellular organismal iron ion homeostasis
- protoporphyrinogen IX metabolic process
- detection of UV
- cholesterol metabolic process
- heme biosynthetic process
- heme a biosynthetic process
- regulation of hemoglobin biosynthetic process
- response to xenobiotic stimulus
- response to light stimulus
- heme b biosynthetic process
- heme O biosynthetic process
- response to ethanol
- erythrocyte differentiation
- response to methylmercury
- response to insecticide
- regulation of eIF2 alpha phosphorylation by heme
- response to platinum ion
- response to arsenic-containing substance
- very-low-density lipoprotein particle assembly
- cellular response to dexamethasone stimulus
- response to lead ion
Cellular Component
Where in the cell the gene product is active
- mitochondrial matrix
- mitochondrion
- mitochondrial inner membrane
Molecular Function
What the gene product does at the molecular level
- ferrochelatase activity
- identical protein binding
- protein homodimerization activity
- protein binding
- ferrous iron binding
- iron-responsive element binding
- 2 iron, 2 sulfur cluster binding
- heme binding