PPARα/RXRα Activation
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The Peroxisome proliferator activated receptor α (PPARα) is a ligand activated transcription factor that belongs to the family of nuclear receptors. PPARα is activated by polyunsaturated fatty acids and synthetic drugs like fibrates. After hetrodimerization with its partner RXRα, PPARα plays a central role in fatty acid oxidation and uptake in tissues like liver, heart, skeletal muscle and kidney. In addition, PPARα is also expressed in endothelial cells, vascular smooth muscle cells and macrophages where it exerts anti-inflammatory and anti-oxidative effects. PPARα agonists decrease the progression of diseases like atherosclerosis and the metabolic syndrome by controlling dyslipidemia, inflammation and glucose intolerance, underscoring PPARα as an important pharmacological target...
Pathway Summary
The Peroxisome proliferator activated receptor α (PPARα) is a ligand activated transcription factor that belongs to the family of nuclear receptors. PPARα is activated by polyunsaturated fatty acids and synthetic drugs like fibrates. After hetrodimerization with its partner RXRα, PPARα plays a central role in fatty acid oxidation and uptake in tissues like liver, heart, skeletal muscle and kidney. In addition, PPARα is also expressed in endothelial cells, vascular smooth muscle cells and macrophages where it exerts anti-inflammatory and anti-oxidative effects. PPARα agonists decrease the progression of diseases like atherosclerosis and the metabolic syndrome by controlling dyslipidemia, inflammation and glucose intolerance, underscoring PPARα as an important pharmacological target.
PPARα/RXRα Activation Genes list
Explore Genes related to PPARα/RXRα Activation
ABCA1
Human
ATP binding cassette subfamily A member 1
ACADL
Human
acyl-CoA dehydrogenase long chain
ADIPOQ
Human
adiponectin, C1Q and collagen domain containing
AIP
Human
aryl hydrocarbon receptor interacting protein
AP2A2
Human
adaptor related protein complex 2 subunit alpha 2
BMPR2
Human
bone morphogenetic protein receptor type 2
CAMP
Human
cathelicidin antimicrobial peptide
CAND1
Human
cullin associated and neddylation dissociated 1
CHD5
Human
chromodomain helicase DNA binding protein 5
CHUK
Human
component of inhibitor of nuclear factor kappa B kinase complex
CKAP5
Human
cytoskeleton associated protein 5
CPT1B
Human
carnitine palmitoyltransferase 1B
CYP2C18
Human
cytochrome P450 family 2 subfamily C member 18
CYP2C19
Human
cytochrome P450 family 2 subfamily C member 19
CYP2C8
Human
cytochrome P450 family 2 subfamily C member 8
CYP2C9
Human
cytochrome P450 family 2 subfamily C member 9
ELP1
Human
elongator acetyltransferase complex subunit 1
GOT2
Human
glutamic-oxaloacetic transaminase 2
GPD1
Human
glycerol-3-phosphate dehydrogenase 1
GPD2
Human
glycerol-3-phosphate dehydrogenase 2
GRB2
Human
growth factor receptor bound protein 2
GUCY1A1
Human
guanylate cyclase 1 soluble subunit alpha 1
GUCY1B1
Human
guanylate cyclase 1 soluble subunit beta 1
HSP90AA1
Human
heat shock protein 90 alpha family class A member 1
HSP90AB1
Human
heat shock protein 90 alpha family class B member 1
HSP90B1
Human
heat shock protein 90 beta family member 1
IKBKB
Human
inhibitor of nuclear factor kappa B kinase subunit beta
IKBKE
Human
inhibitor of nuclear factor kappa B kinase subunit epsilon
IKBKG
Human
inhibitor of nuclear factor kappa B kinase regulatory subunit gamma
IL18RAP
Human
interleukin 18 receptor accessory protein
IL1RAP
Human
interleukin 1 receptor accessory protein
IL1RAPL1
Human
interleukin 1 receptor accessory protein like 1
IL1RAPL2
Human
interleukin 1 receptor accessory protein like 2
JUN
Human
Jun proto-oncogene, AP-1 transcription factor subunit
MAP2K1
Human
mitogen-activated protein kinase kinase 1
MAP2K2
Human
mitogen-activated protein kinase kinase 2
MAP2K3
Human
mitogen-activated protein kinase kinase 3
MAP2K4
Human
mitogen-activated protein kinase kinase 4
MAP2K6
Human
mitogen-activated protein kinase kinase 6
MAP2K7
Human
mitogen-activated protein kinase kinase 7
MAP3K14
Human
mitogen-activated protein kinase kinase kinase 14
MAP3K7
Human
mitogen-activated protein kinase kinase kinase 7
MAP4K4
Human
mitogen-activated protein kinase kinase kinase kinase 4
MAPK1
Human
mitogen-activated protein kinase 1
MAPK14
Human
mitogen-activated protein kinase 14
MAPK3
Human
mitogen-activated protein kinase 3
MAPK8
Human
mitogen-activated protein kinase 8
NFKB1
Human
nuclear factor kappa B subunit 1
NFKB2
Human
nuclear factor kappa B subunit 2
NOTUM
Human
notum, palmitoleoyl-protein carboxylesterase
NR0B2
Human
nuclear receptor subfamily 0 group B member 2
NR2C2
Human
nuclear receptor subfamily 2 group C member 2
NR2F1
Human
nuclear receptor subfamily 2 group F member 1
PDIA3
Human
protein disulfide isomerase family A member 3
PLCL1
Human
phospholipase C like 1 (inactive)
PPARA
Human
peroxisome proliferator activated receptor alpha
PRKAA1
Human
protein kinase AMP-activated catalytic subunit alpha 1
PRKAA2
Human
protein kinase AMP-activated catalytic subunit alpha 2
PRKAB1
Human
protein kinase AMP-activated non-catalytic subunit beta 1
PRKAB2
Human
protein kinase AMP-activated non-catalytic subunit beta 2
PRKACA
Human
protein kinase cAMP-activated catalytic subunit alpha
PRKACB
Human
protein kinase cAMP-activated catalytic subunit beta
PRKACG
Human
protein kinase cAMP-activated catalytic subunit gamma
PRKAG1
Human
protein kinase AMP-activated non-catalytic subunit gamma 1
PRKAG2
Human
protein kinase AMP-activated non-catalytic subunit gamma 2
PRKAG3
Human
protein kinase AMP-activated non-catalytic subunit gamma 3
PRKAR1A
Human
protein kinase cAMP-dependent type I regulatory subunit alpha
PRKAR1B
Human
protein kinase cAMP-dependent type I regulatory subunit beta
PRKAR2A
Human
protein kinase cAMP-dependent type II regulatory subunit alpha
PRKAR2B
Human
protein kinase cAMP-dependent type II regulatory subunit beta
RAF1
Human
Raf-1 proto-oncogene, serine/threonine kinase
RAP1A
Human
RAP1A, member of RAS oncogene family
RAP1B
Human
RAP1B, member of RAS oncogene family
RAP2A
Human
RAP2A, member of RAS oncogene family
RAP2B
Human
RAP2B, member of RAS oncogene family
RASD1
Human
ras related dexamethasone induced 1
REL
Human
REL proto-oncogene, NF-kB subunit
RELA
Human
RELA proto-oncogene, NF-kB subunit
RELB
Human
RELB proto-oncogene, NF-kB subunit
SLC27A1
Human
solute carrier family 27 member 1
SOS1
Human
SOS Ras/Rac guanine nucleotide exchange factor 1
SOS2
Human
SOS Ras/Rho guanine nucleotide exchange factor 2
STAT5B
Human
signal transducer and activator of transcription 5B
TGFB1
Human
transforming growth factor beta 1
TGFB2
Human
transforming growth factor beta 2
TGFB3
Human
transforming growth factor beta 3
TGFBR1
Human
transforming growth factor beta receptor 1
TGFBR2
Human
transforming growth factor beta receptor 2
TGFBR3
Human
transforming growth factor beta receptor 3
TRAF6
Human
TNF receptor associated factor 6
Products related to PPARα/RXRα Activation
Explore products related to PPARα/RXRα Activation
QuantiNova LNA PCR Focus Panel Human PPAR Targets
GeneGlobe ID: SBHS-149Z | Cat. No.: 249950 | QuantiNova LNA PCR Focus Panels
QuantiNova LNA PCR Focus Panel
RT² Profiler™ PCR Array Human PPAR Targets
GeneGlobe ID: PAHS-149Z | Cat. No.: 330231 | RT2 Profiler PCR Arrays
RT2 Profiler PCR Array
QuantiNova LNA Probe PCR Focus Panel Human Nuclear Receptors & Coregulators
GeneGlobe ID: UPHS-056Z | Cat. No.: 249955 | QuantiNova LNA Probe PCR Focus Panels
QuantiNova LNA Probe PCR Focus Panel
QuantiNova LNA PCR Focus Panel Human Nuclear Receptors & Coregulators
GeneGlobe ID: SBHS-056Z | Cat. No.: 249950 | QuantiNova LNA PCR Focus Panels
QuantiNova LNA PCR Focus Panel
QuantiNova LNA Probe PCR Focus Panel Human PPAR Targets
GeneGlobe ID: UPHS-149Z | Cat. No.: 249955 | QuantiNova LNA Probe PCR Focus Panels
QuantiNova LNA Probe PCR Focus Panel
RT² Profiler™ PCR Array Human Nuclear Receptors & Coregulators
GeneGlobe ID: PAHS-056Z | Cat. No.: 330231 | RT2 Profiler PCR Arrays
RT2 Profiler PCR Array