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PPARα/RXRα Activation

The Peroxisome proliferator activated receptor α (PPARα) is a ligand activated transcription factor that belongs to the family of nuclear receptors. PPARα is activated by polyunsaturated fatty acids and synthetic drugs like fibrates. After hetrodimerization with its partner RXRα, PPARα plays a central role in fatty acid oxidation and uptake in tissues like liver, heart, skeletal muscle and kidney. In addition, PPARα is also expressed in endothelial cells, vascular smooth muscle cells and macrophages where it exerts anti-inflammatory and anti-oxidative effects. PPARα agonists decrease the progression of diseases like atherosclerosis and the metabolic syndrome by controlling dyslipidemia, inflammation and glucose intolerance, underscoring PPARα as an important pharmacological target...

PPARα/RXRα Activation

Pathway Summary

The Peroxisome proliferator activated receptor α (PPARα) is a ligand activated transcription factor that belongs to the family of nuclear receptors. PPARα is activated by polyunsaturated fatty acids and synthetic drugs like fibrates. After hetrodimerization with its partner RXRα, PPARα plays a central role in fatty acid oxidation and uptake in tissues like liver, heart, skeletal muscle and kidney. In addition, PPARα is also expressed in endothelial cells, vascular smooth muscle cells and macrophages where it exerts anti-inflammatory and anti-oxidative effects. PPARα agonists decrease the progression of diseases like atherosclerosis and the metabolic syndrome by controlling dyslipidemia, inflammation and glucose intolerance, underscoring PPARα as an important pharmacological target.

PPARα/RXRα Activation Genes list

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GeneGlobe ID: UPHS-056Z | Cat. No.: 249955 | QuantiNova LNA Probe PCR Focus Panels
QuantiNova LNA Probe PCR Focus Panel Human Nuclear Receptors & Coregulators
QuantiNova LNA Probe PCR Focus Panel
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GeneGlobe ID: PAHS-056Z | Cat. No.: 330231 | RT2 Profiler PCR Arrays
RT² Profiler™ PCR Array Human Nuclear Receptors & Coregulators
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GeneGlobe ID: PAHS-149Z | Cat. No.: 330231 | RT2 Profiler PCR Arrays
RT² Profiler™ PCR Array Human PPAR Targets
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GeneGlobe ID: UPHS-149Z | Cat. No.: 249955 | QuantiNova LNA Probe PCR Focus Panels
QuantiNova LNA Probe PCR Focus Panel Human PPAR Targets
QuantiNova LNA Probe PCR Focus Panel
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GeneGlobe ID: SBHS-056Z | Cat. No.: 249950 | QuantiNova LNA PCR Focus Panels
QuantiNova LNA PCR Focus Panel Human Nuclear Receptors & Coregulators
QuantiNova LNA PCR Focus Panel
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GeneGlobe ID: SBHS-149Z | Cat. No.: 249950 | QuantiNova LNA PCR Focus Panels
QuantiNova LNA PCR Focus Panel Human PPAR Targets
QuantiNova LNA PCR Focus Panel
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