Bsnd Gene Summary [Mouse]
Enables chloride channel regulator activity. Contributes to chloride channel activity. Involved in sensory perception of sound. Located in basolateral plasma membrane. Part of protein-containing complex. Is expressed in central nervous system; inner ear; and metanephros. Used to study Bartter disease type 4a. Human ortholog(s) of this gene implicated in Bartter disease; Bartter disease type 4a; and sensorineural hearing loss. Orthologous to human BSND (barttin CLCNK type accessory subunit beta). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Bsnd |
| Official Name | barttin CLCNK type accessory beta subunit [Source:MGI Symbol;Acc:MGI:2153465] |
| Ensembl ID | ENSMUSG00000025418 |
| Bio databases IDs | |
| Aliases | barttin CLCNK type accessory beta subunit |
| Synonyms | BART, BARTTIN, barttin CLCNK type accessory beta subunit, barttin CLCNK type accessory subunit beta, barttin CLCNK type accessory subunit β, barttin CLCNK type accessory β subunit, DFNB73 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Bsnd often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Bartter syndrome, infantile, with sensorineural deafness (Barttin)
- chloride channel
- protein binding
- chloride channel regulator
- ion channel
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- diabetic nephropathy
- chronic kidney disease
- Bartter syndrome type 4A
- Bartter syndrome
- Bartter syndrome type 4
- Bartter syndrome with sensorineural deafness
- allergic rhinitis
- angina pectoris
- plantar wart
- autosomal recessive deafness
regulates
- chloride
role in cell
- 5-fluorouracil resistance
- ion homeostasis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
- basolateral membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Bsnd gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- chloride transport
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- macromolecular complex
- basolateral plasma membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- chloride channel regulator activity
- protein binding
- chloride channel activity