Plscr2 Gene Summary [Mouse]
Predicted to enable several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; metal ion binding activity; and signaling receptor binding activity. Involved in cellular response to lipopolysaccharide. Located in cytoplasm and nucleus. Is expressed in foregut; inner ear; mesothelium; and urogenital mesentery. Orthologous to several human genes including PLSCR1 (phospholipid scramblase 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Plscr2 |
| Official Name | phospholipid scramblase 2 [Source:MGI Symbol;Acc:MGI:1270860] |
| Ensembl ID | ENSMUSG00000032372 |
| Bio databases IDs | |
| Aliases | phospholipid scramblase 2 |
| Synonyms | phospholipid scramblase 2, Plscr1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Plscr2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- viral receptor
- nuclease
- epidermal growth factor receptor binding
- calcium ion binding
- metal ion binding
- enzyme binding
- enzyme
- protein binding
- magnesium ion binding
- SH3-domain binding
- LURP-one-related
- CD4 receptor binding
- zinc ion binding
- phospholipid scramblase
- mercury ion binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular membrane-bounded organelle
- perinuclear region
- cellular membrane
- Nucleus
- Plasma Membrane
- Golgi Apparatus
- Endoplasmic Reticulum
- cytosol
- nucleoplasm
- nucleoli
- extracellular matrix
- membrane rafts
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Plscr2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- phospholipid scrambling
Cellular Component
Where in the cell the gene product is active
- intracellular membrane-bounded organelle
- endoplasmic reticulum
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- calcium ion binding
- phospholipid scramblase activity